Znaky genové exprese pro spontánní regresi nádorů u melanomových prasat

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F08%3A00325015" target="_blank" >RIV/67985904:_____/08:00325015 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Gene expression signature for spontaneous cancer regression in melanoma pigs

Popis výsledku v původním jazyce

Incomplete spontaneous regression of melanoma is common. However, complete melanoma regression is still a very rare phenomenon. Melanoma is the most immunogenic human malignancy. The mechanisms leading to its regression are the host?s immune responses. Unfortunately, therapies aiming to enhance the patient?s natural immunity against melanoma have yet to meet their expectations. Reasons for failure include various immune escape mechanisms, induced by the tumour, that subsequently lead to tolerance. Here,we monitored changes of gene expression profiles involved in the transition of progressive melanoma to complete tumour regression using a porcine model. The melanoblastoma-bearing Libechov minipigs are highly suitable for this study because these animals exhibit naturally occurring and regressing melanomas. We were able to identify a molecular signature of the melanoma regression process. Genes regulated in this process were associated with 1) cell cycle, 2) immune response, and 3) mela

Název v anglickém jazyce

Gene expression signature for spontaneous cancer regression in melanoma pigs

Popis výsledku anglicky

Incomplete spontaneous regression of melanoma is common. However, complete melanoma regression is still a very rare phenomenon. Melanoma is the most immunogenic human malignancy. The mechanisms leading to its regression are the host?s immune responses. Unfortunately, therapies aiming to enhance the patient?s natural immunity against melanoma have yet to meet their expectations. Reasons for failure include various immune escape mechanisms, induced by the tumour, that subsequently lead to tolerance. Here,we monitored changes of gene expression profiles involved in the transition of progressive melanoma to complete tumour regression using a porcine model. The melanoblastoma-bearing Libechov minipigs are highly suitable for this study because these animals exhibit naturally occurring and regressing melanomas. We were able to identify a molecular signature of the melanoma regression process. Genes regulated in this process were associated with 1) cell cycle, 2) immune response, and 3) mela

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neoplasia

ISSN

1522-8002

e-ISSN

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Svazek periodika

10

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

13

Strana od-do

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Kód UT WoS článku

000256768800010

EID výsledku v databázi Scopus

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