Spontaneous regression of tumour and the role of microbial infection - possibilities for cancer treatment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F16%3A00460687" target="_blank" >RIV/67985904:_____/16:00460687 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064211:_____/16:N0000038

Výsledek na webu

<a href="http://dx.doi.org/10.1097/CAD.0000000000000337" target="_blank" >http://dx.doi.org/10.1097/CAD.0000000000000337</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/CAD.0000000000000337" target="_blank" >10.1097/CAD.0000000000000337</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Spontaneous regression of tumour and the role of microbial infection - possibilities for cancer treatment

Popis výsledku v původním jazyce

This review deals with the role of microorganisms in spontaneous regression of a tumour. Spontaneous cancer regression is a phenomenon that has been described for many centuries. One of the most well known methods of inducing spontaneous regression of cancer is the application of Coley's toxin (heat-killed Streptococcus pyogenes and Serratia marcescens), which has been used for the successful treatment of sarcomas, carcinomas, lymphomas, myelomas and melanomas. In clinical practice, the use of Bacillus Calmette-Guerin vaccine for the treatment of superficial urinary bladder cancer is the most common instance of the application of microorganisms for the treatment of cancer. This review provides further information on other tested bacteria - Clostridium spp., Bifidobacterium spp., Lactobacillus spp. and Salmonella spp. - in this field of study. Among new age methods, bactofection, alternative gene therapy, combination bacteriolytic therapy and bacteria-directed enzyme prodrug therapy are some of the potential cancer treatment modalities that use microorganisms. We have also provided information about the interconnection among microorganisms, immune system response, and the possible mechanisms involved in the spontaneous regression of tumours.

Název v anglickém jazyce

Spontaneous regression of tumour and the role of microbial infection - possibilities for cancer treatment

Popis výsledku anglicky

This review deals with the role of microorganisms in spontaneous regression of a tumour. Spontaneous cancer regression is a phenomenon that has been described for many centuries. One of the most well known methods of inducing spontaneous regression of cancer is the application of Coley's toxin (heat-killed Streptococcus pyogenes and Serratia marcescens), which has been used for the successful treatment of sarcomas, carcinomas, lymphomas, myelomas and melanomas. In clinical practice, the use of Bacillus Calmette-Guerin vaccine for the treatment of superficial urinary bladder cancer is the most common instance of the application of microorganisms for the treatment of cancer. This review provides further information on other tested bacteria - Clostridium spp., Bifidobacterium spp., Lactobacillus spp. and Salmonella spp. - in this field of study. Among new age methods, bactofection, alternative gene therapy, combination bacteriolytic therapy and bacteria-directed enzyme prodrug therapy are some of the potential cancer treatment modalities that use microorganisms. We have also provided information about the interconnection among microorganisms, immune system response, and the possible mechanisms involved in the spontaneous regression of tumours.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

—

Projekt

<a href="/cs/project/ED2.1.00%2F03.0124" target="_blank" >ED2.1.00/03.0124: ExAM Experimental Animal Models</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Anti-cancer Drugs

ISSN

0959-4973

e-ISSN

—

Svazek periodika

27

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

269-277

Kód UT WoS článku

000373774900001

EID výsledku v databázi Scopus

2-s2.0-84961200129