Importance of ERK1/2 in Regulation of Protein Translation during Oocyte Meiosis
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F18%3A00492350" target="_blank" >RIV/67985904:_____/18:00492350 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11310/18:10403777
Výsledek na webu
<a href="http://dx.doi.org/10.3390/ijms19030698" target="_blank" >http://dx.doi.org/10.3390/ijms19030698</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms19030698" target="_blank" >10.3390/ijms19030698</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Importance of ERK1/2 in Regulation of Protein Translation during Oocyte Meiosis
Popis výsledku v původním jazyce
Although the involvement of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) pathway in the regulation of cytostatic factor (CSF) aktivity, as well as in microtubules organization during meiotic maturation of oocytes, has already been described in detail, rather less attention has been paid to the role of ERK1/2 in the regulation of mRNA translation. However, important data on the role of ERK1/2 in translation during oocyte meiosis have been documented. This review focuses on recent findings regarding the regulation of translation and the role of ERK1/2 in this process in the meiotic cycle of mammalian oocytes. The specific role of ERK1/2 in the regulation of mammalian target of rapamycin (mTOR), eukaryotic translation initiation factor 4E (eIF4E) and cytoplasmic polyadenylation element binding protein 1 (CPEB1) activity is addressed along with additional focus on the other key players involved in protein translation.
Název v anglickém jazyce
Importance of ERK1/2 in Regulation of Protein Translation during Oocyte Meiosis
Popis výsledku anglicky
Although the involvement of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) pathway in the regulation of cytostatic factor (CSF) aktivity, as well as in microtubules organization during meiotic maturation of oocytes, has already been described in detail, rather less attention has been paid to the role of ERK1/2 in the regulation of mRNA translation. However, important data on the role of ERK1/2 in translation during oocyte meiosis have been documented. This review focuses on recent findings regarding the regulation of translation and the role of ERK1/2 in this process in the meiotic cycle of mammalian oocytes. The specific role of ERK1/2 in the regulation of mammalian target of rapamycin (mTOR), eukaryotic translation initiation factor 4E (eIF4E) and cytoplasmic polyadenylation element binding protein 1 (CPEB1) activity is addressed along with additional focus on the other key players involved in protein translation.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10608 - Biochemistry and molecular biology
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2018
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
—
Svazek periodika
19
Číslo periodika v rámci svazku
3
Stát vydavatele periodika
CH - Švýcarská konfederace
Počet stran výsledku
21
Strana od-do
—
Kód UT WoS článku
000428309800055
EID výsledku v databázi Scopus
2-s2.0-85042787387