Retinal abnormatilites as a diagnostic or prognostic marker of schizophrenia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F18%3A00495782" target="_blank" >RIV/67985904:_____/18:00495782 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14310/18:00106671 RIV/00179906:_____/18:10379398 RIV/00216208:11150/18:10379398

Výsledek na webu

<a href="http://dx.doi.org/10.5507/bp.2018.035" target="_blank" >http://dx.doi.org/10.5507/bp.2018.035</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2018.035" target="_blank" >10.5507/bp.2018.035</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Retinal abnormatilites as a diagnostic or prognostic marker of schizophrenia

Popis výsledku v původním jazyce

The review is a summary of structural and functional changes in the human retina observed in patients with schizophrenia. The main focus is on the potential of these changes to serve as schizophrenia-specific biomarkers accessible to clinicians. We identified three features of the retina that can be detected non-invasively in humans and which appear to show charateristic changes in schizophrenia: (1) retinal microvasculature displaying abnormally wide venules, (2) electroretinograms indicating altered function of photoreceptors or other cells in the retinal component of the visual pathway, (3) optical coherence tomography pointing to structural differences between the retinae of patients with schizophrenia and those of healthy volunteers. We propose that the most feasible approach to evaluating the data would be to study the genetic and epigenetic background of the schizophrenia-associated retinal abnormalities and establish their significance and specificity as potential biomarkers for the disease. The studies should include longitudinal observations focusing on the possible involvement of medication and comorbid conditions in the mechanism of the disease, a comparison of schizophrenia with other mental disorders, and investigating retinal abnormalities in animal models of psychoses. Biomarkers identified in the process could represent an important addition to the arsenal of non-invasive techniques available to both clinicians and researchers. These novel biomarkers could facilitate research of the biological basis of psychosis and help to address the diagnostic, predicitive, preventative, prophylactic and therapeutic aspects of schizophrenia.

Název v anglickém jazyce

Retinal abnormatilites as a diagnostic or prognostic marker of schizophrenia

Popis výsledku anglicky

The review is a summary of structural and functional changes in the human retina observed in patients with schizophrenia. The main focus is on the potential of these changes to serve as schizophrenia-specific biomarkers accessible to clinicians. We identified three features of the retina that can be detected non-invasively in humans and which appear to show charateristic changes in schizophrenia: (1) retinal microvasculature displaying abnormally wide venules, (2) electroretinograms indicating altered function of photoreceptors or other cells in the retinal component of the visual pathway, (3) optical coherence tomography pointing to structural differences between the retinae of patients with schizophrenia and those of healthy volunteers. We propose that the most feasible approach to evaluating the data would be to study the genetic and epigenetic background of the schizophrenia-associated retinal abnormalities and establish their significance and specificity as potential biomarkers for the disease. The studies should include longitudinal observations focusing on the possible involvement of medication and comorbid conditions in the mechanism of the disease, a comparison of schizophrenia with other mental disorders, and investigating retinal abnormalities in animal models of psychoses. Biomarkers identified in the process could represent an important addition to the arsenal of non-invasive techniques available to both clinicians and researchers. These novel biomarkers could facilitate research of the biological basis of psychosis and help to address the diagnostic, predicitive, preventative, prophylactic and therapeutic aspects of schizophrenia.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30215 - Psychiatry

Projekt

<a href="/cs/project/NV16-27243A" target="_blank" >NV16-27243A: Mikrovaskulární abnormality jakožto endofenotyp schizofrenie</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical Papers

ISSN

1213-8118

e-ISSN

—

Svazek periodika

162

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

6

Strana od-do

159-164

Kód UT WoS článku

000445913000001

EID výsledku v databázi Scopus

2-s2.0-85053732474