Age-related macular degeneration and modern aspects of therapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F20%3A00536563" target="_blank" >RIV/67985904:_____/20:00536563 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Age-related macular degeneration and modern aspects of therapy

Popis výsledku v původním jazyce

Age-related macular degeneration (AMD) is a widespread worldwide disease in population over 60 years old. The macula and its retinal pigment epithelial cells (RPE) are influenced by AMD and patients can lose central vision. It can limit reading, driving a car, recognizing faces – living normal life. AMD consists of two types – wet and dry form. The wet form is treatable by injection of anti-VEGF. On the other hand, the dry form is still not treatable and it is subject of research. It includes RPE or stem cell transplantation, macular translocation or gene therapy. The cell transplantation includes injecting suspensions of RPE cells, transplanting RPE cell sheets or inserting membranes with cultivated RPE cells. Primary cells, embryonic stem cells or induced pluripotent stem cells can be used for RPE cell transplantation. Another surgical procedure can be macular translocation, which describes delivering healthy macular mass into an area with healthy RPE cells. But this procedure has been largely abandoned due to poor outcomes. The last described treatment is gene therapy, which can turn the cells of the inner retina into “replacement photoreceptors”.

Název v anglickém jazyce

Age-related macular degeneration and modern aspects of therapy

Popis výsledku anglicky

Age-related macular degeneration (AMD) is a widespread worldwide disease in population over 60 years old. The macula and its retinal pigment epithelial cells (RPE) are influenced by AMD and patients can lose central vision. It can limit reading, driving a car, recognizing faces – living normal life. AMD consists of two types – wet and dry form. The wet form is treatable by injection of anti-VEGF. On the other hand, the dry form is still not treatable and it is subject of research. It includes RPE or stem cell transplantation, macular translocation or gene therapy. The cell transplantation includes injecting suspensions of RPE cells, transplanting RPE cell sheets or inserting membranes with cultivated RPE cells. Primary cells, embryonic stem cells or induced pluripotent stem cells can be used for RPE cell transplantation. Another surgical procedure can be macular translocation, which describes delivering healthy macular mass into an area with healthy RPE cells. But this procedure has been largely abandoned due to poor outcomes. The last described treatment is gene therapy, which can turn the cells of the inner retina into “replacement photoreceptors”.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

30207 - Ophthalmology

Projekt

<a href="/cs/project/LO1609" target="_blank" >LO1609: Modely závažných lidských onemocnění: Traumatické poškození míchy, Huntingtonova choroba, melanom a neplodnost</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Translational Research in Serious Human Diseases

ISBN

978-80-200-3158-7

Počet stran výsledku

6

Strana od-do

154-159

Počet stran knihy

271

Název nakladatele

Academia

Místo vydání

Praha

Kód UT WoS kapitoly

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