Retinal Pigment Epithelium Cell Development: Extrapolating Basic Biology to Stem Cell Research

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F23%3A00572494" target="_blank" >RIV/67985904:_____/23:00572494 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/23:00572494 RIV/61389013:_____/23:00572494

Výsledek na webu

<a href="https://www.mdpi.com/2227-9059/11/2/310" target="_blank" >https://www.mdpi.com/2227-9059/11/2/310</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/biomedicines11020310" target="_blank" >10.3390/biomedicines11020310</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Retinal Pigment Epithelium Cell Development: Extrapolating Basic Biology to Stem Cell Research

Popis výsledku v původním jazyce

The retinal pigment epithelium (RPE) forms an important cellular monolayer, which contributes to the normal physiology of the eye. Damage to the RPE leads to the development of degenerative diseases, such as age-related macular degeneration (AMD). Apart from acting as a physical barrier between the retina and choroidal blood vessels, the RPE is crucial in maintaining photoreceptor (PR) and visual functions. Current clinical intervention to treat early stages of AMD includes stem cell-derived RPE transplantation, which is still in its early stages of evolution. Therefore, it becomes essential to derive RPEs which are functional and exhibit features as observed in native human RPE cells. The conventional strategy is to use the knowledge obtained from developmental studies using various animal models and stem cell-based exploratory studies to understand RPE biogenies and developmental trajectory. This article emphasises such studies and aims to present a comprehensive understanding of the basic biology, including the genetics and molecular pathways of RPE development. It encompasses basic developmental biology and stem cell-based developmental studies to uncover RPE differentiation. Knowledge of the in utero developmental cues provides an inclusive methodology required for deriving RPEs using stem cells.

Název v anglickém jazyce

Retinal Pigment Epithelium Cell Development: Extrapolating Basic Biology to Stem Cell Research

Popis výsledku anglicky

The retinal pigment epithelium (RPE) forms an important cellular monolayer, which contributes to the normal physiology of the eye. Damage to the RPE leads to the development of degenerative diseases, such as age-related macular degeneration (AMD). Apart from acting as a physical barrier between the retina and choroidal blood vessels, the RPE is crucial in maintaining photoreceptor (PR) and visual functions. Current clinical intervention to treat early stages of AMD includes stem cell-derived RPE transplantation, which is still in its early stages of evolution. Therefore, it becomes essential to derive RPEs which are functional and exhibit features as observed in native human RPE cells. The conventional strategy is to use the knowledge obtained from developmental studies using various animal models and stem cell-based exploratory studies to understand RPE biogenies and developmental trajectory. This article emphasises such studies and aims to present a comprehensive understanding of the basic biology, including the genetics and molecular pathways of RPE development. It encompasses basic developmental biology and stem cell-based developmental studies to uncover RPE differentiation. Knowledge of the in utero developmental cues provides an inclusive methodology required for deriving RPEs using stem cells.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10601 - Cell biology

Projekt

<a href="/cs/project/TO01000107" target="_blank" >TO01000107: Standardizované kultivace, transplantace a uchovávání RPE buněk za účelem léčení věkem-podmíněné makulární degenerace (AMD)</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedicines

ISSN

2227-9059

e-ISSN

2227-9059

Svazek periodika

11

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

19

Strana od-do

310

Kód UT WoS článku

000938856800001

EID výsledku v databázi Scopus

2-s2.0-85148855811