Association between polymorphism rs2421943 of the insulin-degrading enzyme and schizophrenia: Preliminary report

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F23%3A00576044" target="_blank" >RIV/67985904:_____/23:00576044 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14310/23:00134349 RIV/61989592:15110/23:73621295

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1002/jcla.24949" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/jcla.24949</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jcla.24949" target="_blank" >10.1002/jcla.24949</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Association between polymorphism rs2421943 of the insulin-degrading enzyme and schizophrenia: Preliminary report

Popis výsledku v původním jazyce

BackgroundInsulin-degrading enzyme (IDE) is an important gene in studies of the pathophysiology of type 2 diabetes mellitus (T2DM). Recent studies have suggested a possible link between type 2 diabetes mellitus (T2DM) and the pathophysiology of schizophrenia (SZ). At the same time, significant changes in insulin-degrading enzyme (IDE) gene expression have been found in the brains of people with schizophrenia. These findings highlight the need to further investigate the role of IDE in schizophrenia pathogenesis. MethodsWe enrolled 733 participants from the Czech Republic, including 383 patients with schizophrenia and 350 healthy controls. Our study focused on the single nucleotide polymorphism (SNP) rs2421943 in the IDE gene, which has previously been associated with the pathogenesis of Alzheimer's disease. The SNP was analyzed using the PCR-RFLP method. ResultsThe G allele of the rs2421943 polymorphism was found to significantly increase the risk of developing SZ (p < 0.01) when a gender-based analysis showed that both AG and GG genotypes were associated with a more than 1.55 times increased risk of SZ in females (p < 0.03) but not in males. Besides, we identified a potential binding site at the G allele locus for has-miR-7110-5p, providing a potential mechanism for the observed association. ConclusionOur results confirm the role of the IDE gene in schizophrenia pathogenesis and suggest that future research should investigate the relationship between miRNA and estrogen influence on IDE expression in schizophrenia pathogenesis.

Název v anglickém jazyce

Association between polymorphism rs2421943 of the insulin-degrading enzyme and schizophrenia: Preliminary report

Popis výsledku anglicky

BackgroundInsulin-degrading enzyme (IDE) is an important gene in studies of the pathophysiology of type 2 diabetes mellitus (T2DM). Recent studies have suggested a possible link between type 2 diabetes mellitus (T2DM) and the pathophysiology of schizophrenia (SZ). At the same time, significant changes in insulin-degrading enzyme (IDE) gene expression have been found in the brains of people with schizophrenia. These findings highlight the need to further investigate the role of IDE in schizophrenia pathogenesis. MethodsWe enrolled 733 participants from the Czech Republic, including 383 patients with schizophrenia and 350 healthy controls. Our study focused on the single nucleotide polymorphism (SNP) rs2421943 in the IDE gene, which has previously been associated with the pathogenesis of Alzheimer's disease. The SNP was analyzed using the PCR-RFLP method. ResultsThe G allele of the rs2421943 polymorphism was found to significantly increase the risk of developing SZ (p < 0.01) when a gender-based analysis showed that both AG and GG genotypes were associated with a more than 1.55 times increased risk of SZ in females (p < 0.03) but not in males. Besides, we identified a potential binding site at the G allele locus for has-miR-7110-5p, providing a potential mechanism for the observed association. ConclusionOur results confirm the role of the IDE gene in schizophrenia pathogenesis and suggest that future research should investigate the relationship between miRNA and estrogen influence on IDE expression in schizophrenia pathogenesis.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Clinical Laboratory Analysis

ISSN

0887-8013

e-ISSN

1098-2825

Svazek periodika

37

Číslo periodika v rámci svazku

13-14

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

e24949

Kód UT WoS článku

001036281600001

EID výsledku v databázi Scopus

2-s2.0-85166405685