The Role of Gene for Insulin Degrading Enzyme in the Pathogenesis of Schizophrenia

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The Role of Gene for Insulin Degrading Enzyme in the Pathogenesis of Schizophrenia

Popis výsledku v původním jazyce

Objectives The Insulin Degrading Enzyme (IDE) degrades intracellular insulin and other peptides. The IDE gene has been previously associated with type 2 diabetes mellitus1. The prevalence of diabetes is increased 2- to 3- fold in patients with schizophrenia2. Our objective was therefore to examine the association of IDE gene polymorphisms with the schizophrenia. Methods The association between IDE gene polymorphisms and schizophrenia has been studied in our case-control study involving 400 patients and 400 control subjects. The DNA was extracted from full blood samples and analyzed by the SNaPshot multiplex method on a genetic analyzer ABI PRISM 3100. Results In our study we have found statistically significant association between schizophrenia and one single nucleotide polymorphism (SNP) of the IDE gene. The AA genotype of rs2421943 polymorphism shows a protective role, it decreases the risk of schizophrenia 0,76-fold (p = 0,01) and A allele decreases the risk 0,87-fold (p = 0,007). Conclusions Our study shows, that the comorbidity between schizophrenia and diabetes mellitus might have common genetic roots and IDE gene could become new candidate gene for further research of genetic causes of schizophrenia.

Název v anglickém jazyce

The Role of Gene for Insulin Degrading Enzyme in the Pathogenesis of Schizophrenia

Popis výsledku anglicky

Objectives The Insulin Degrading Enzyme (IDE) degrades intracellular insulin and other peptides. The IDE gene has been previously associated with type 2 diabetes mellitus1. The prevalence of diabetes is increased 2- to 3- fold in patients with schizophrenia2. Our objective was therefore to examine the association of IDE gene polymorphisms with the schizophrenia. Methods The association between IDE gene polymorphisms and schizophrenia has been studied in our case-control study involving 400 patients and 400 control subjects. The DNA was extracted from full blood samples and analyzed by the SNaPshot multiplex method on a genetic analyzer ABI PRISM 3100. Results In our study we have found statistically significant association between schizophrenia and one single nucleotide polymorphism (SNP) of the IDE gene. The AA genotype of rs2421943 polymorphism shows a protective role, it decreases the risk of schizophrenia 0,76-fold (p = 0,01) and A allele decreases the risk 0,87-fold (p = 0,007). Conclusions Our study shows, that the comorbidity between schizophrenia and diabetes mellitus might have common genetic roots and IDE gene could become new candidate gene for further research of genetic causes of schizophrenia.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů