The relationship between IDE gene polymorphism and Alzheimer's disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F18%3A00105134" target="_blank" >RIV/00216224:14310/18:00105134 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The relationship between IDE gene polymorphism and Alzheimer's disease

Popis výsledku v původním jazyce

Alzheimer’s disease (AD) is a serious neurodegenerative illness related to yearly increasing percentage of affected population. Currently there is no known primary cause of the pathogenesis of AD, and thus it is assumed that it is the interplay of several factors. It can be supposed that heredity also participates in the late-onset AD, but in these cases, there is mostly no comprehensive information about family history due to the high age of patients. For several years, association studies have been trying to find genes that could play a role in increased risk of late onset AD. Studies focused on the molecular mechanisms of Alzheimer’s disease could contribute to an earlier diagnosis and a successful treatment. In our study, we were focused on IDE gene encoding insulin-degrading enzyme, which has a robust capacity to degrade beta amyloid protein, one of the major pathological proteins involved in Alzheimer’s disease pathogenesis. In our research, we examined DNA samples of patients with Alzheimer’s disease and also control subjects, originating from the Czech Republic. Rs2421943 polymorphism of IDE gene was analyzed. For this purpose, the restriction fragment length polymorphism method was used to identify single-nucleotide polymorphism in IDE gene. We found statistically significant association between this polymorphism and the risk of Alzheimer’s disease. Insulin-degrading enzyme can participate in interactions with beta amyloid protein and it can affect the pathogenic processes involved in Alzheimer’s disease.

Název v anglickém jazyce

The relationship between IDE gene polymorphism and Alzheimer's disease

Popis výsledku anglicky

Alzheimer’s disease (AD) is a serious neurodegenerative illness related to yearly increasing percentage of affected population. Currently there is no known primary cause of the pathogenesis of AD, and thus it is assumed that it is the interplay of several factors. It can be supposed that heredity also participates in the late-onset AD, but in these cases, there is mostly no comprehensive information about family history due to the high age of patients. For several years, association studies have been trying to find genes that could play a role in increased risk of late onset AD. Studies focused on the molecular mechanisms of Alzheimer’s disease could contribute to an earlier diagnosis and a successful treatment. In our study, we were focused on IDE gene encoding insulin-degrading enzyme, which has a robust capacity to degrade beta amyloid protein, one of the major pathological proteins involved in Alzheimer’s disease pathogenesis. In our research, we examined DNA samples of patients with Alzheimer’s disease and also control subjects, originating from the Czech Republic. Rs2421943 polymorphism of IDE gene was analyzed. For this purpose, the restriction fragment length polymorphism method was used to identify single-nucleotide polymorphism in IDE gene. We found statistically significant association between this polymorphism and the risk of Alzheimer’s disease. Insulin-degrading enzyme can participate in interactions with beta amyloid protein and it can affect the pathogenic processes involved in Alzheimer’s disease.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů