Quantitative and qualitative differences in the activation of a fibroblast growth factor receptor by different FGF ligands

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F24%3A00597897" target="_blank" >RIV/67985904:_____/24:00597897 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/24:00137051 RIV/00159816:_____/24:00081491

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1359610124000443?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1359610124000443?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cytogfr.2024.07.002" target="_blank" >10.1016/j.cytogfr.2024.07.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Quantitative and qualitative differences in the activation of a fibroblast growth factor receptor by different FGF ligands

Popis výsledku v původním jazyce

The FGF system is the most complex of all receptor tyrosine kinase signaling networks with 18 FGF ligands and four FGFRs that deliver morphogenic signals to pattern most embryonic structures. Even when a single FGFR is expressed in the tissue, different FGFs can trigger dramatically different biological responses via this receptor. Here we show both quantitative and qualitative differences in the signaling of one of the FGF receptors, FGFR1c, in response to different FGFs. We provide an overview of the recent discovery that FGFs engage in biased signaling via FGFR1c. We discuss the concept of ligand bias, which represents qualitative differences in signaling as it is a measure of differential ligand preferences for different downstream responses. We show how FGF ligand bias manifests in functional data in cultured chondrocyte cells. We argue that FGF-ligand bias contributes substantially to FGF-driven developmental processes, along with known differences in FGF expression levels, FGF-FGFR binding coefficients and differences in FGF stability in vivo.

Název v anglickém jazyce

Quantitative and qualitative differences in the activation of a fibroblast growth factor receptor by different FGF ligands

Popis výsledku anglicky

The FGF system is the most complex of all receptor tyrosine kinase signaling networks with 18 FGF ligands and four FGFRs that deliver morphogenic signals to pattern most embryonic structures. Even when a single FGFR is expressed in the tissue, different FGFs can trigger dramatically different biological responses via this receptor. Here we show both quantitative and qualitative differences in the signaling of one of the FGF receptors, FGFR1c, in response to different FGFs. We provide an overview of the recent discovery that FGFs engage in biased signaling via FGFR1c. We discuss the concept of ligand bias, which represents qualitative differences in signaling as it is a measure of differential ligand preferences for different downstream responses. We show how FGF ligand bias manifests in functional data in cultured chondrocyte cells. We argue that FGF-ligand bias contributes substantially to FGF-driven developmental processes, along with known differences in FGF expression levels, FGF-FGFR binding coefficients and differences in FGF stability in vivo.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10605 - Developmental biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cytokine & Growth Factor Reviews

ISSN

1359-6101

e-ISSN

1879-0305

Svazek periodika

78

Číslo periodika v rámci svazku

AUG 24

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

77-84

Kód UT WoS článku

001297450100001

EID výsledku v databázi Scopus

2-s2.0-85199151120