Caspase-12 affects chondrogenesis in mice

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F25%3A00618657" target="_blank" >RIV/67985904:_____/25:00618657 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16170/25:43881484

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0940960224001390?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0940960224001390?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.aanat.2024.152347" target="_blank" >10.1016/j.aanat.2024.152347</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Caspase-12 affects chondrogenesis in mice

Popis výsledku v původním jazyce

Caspase-12 is a molecule whose functions are still not well understood. Although its expression has been found in various tissues, specific roles have been described in only a few cases. These include the effect of caspase-12 on murine bone cell differentiation during craniofacial development. This work focused on the development of the limbs taking place through endochondral ossification, which precedes the formation of the cartilaginous growth plate. Caspase-12 was described here for the first time in growth plate chondrocytes during physiological development. Using pharmacological inhibition, caspase-12 was found to affect chondrogenesis. Limb-derived micromass cultures showed a significantly increased area of chondrogenic nodules after caspase-12 inhibition and there were changes in gene expression, the most significant of which was the reduction of Mmp9. These data point to potential new functions of caspase-12 in chondrogenesis.

Název v anglickém jazyce

Caspase-12 affects chondrogenesis in mice

Popis výsledku anglicky

Caspase-12 is a molecule whose functions are still not well understood. Although its expression has been found in various tissues, specific roles have been described in only a few cases. These include the effect of caspase-12 on murine bone cell differentiation during craniofacial development. This work focused on the development of the limbs taking place through endochondral ossification, which precedes the formation of the cartilaginous growth plate. Caspase-12 was described here for the first time in growth plate chondrocytes during physiological development. Using pharmacological inhibition, caspase-12 was found to affect chondrogenesis. Limb-derived micromass cultures showed a significantly increased area of chondrogenic nodules after caspase-12 inhibition and there were changes in gene expression, the most significant of which was the reduction of Mmp9. These data point to potential new functions of caspase-12 in chondrogenesis.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10605 - Developmental biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Annals of Anatomy-Anatomischer Anzeiger

ISSN

0940-9602

e-ISSN

1618-0402

Svazek periodika

257

Číslo periodika v rámci svazku

Jan 25

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

152347

Kód UT WoS článku

001346123400001

EID výsledku v databázi Scopus

2-s2.0-85207281475