Extensive Admixture and Selective Pressure Across the Sahel Belt

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985912%3A_____%2F15%3A00453905" target="_blank" >RIV/67985912:_____/15:00453905 - isvavai.cz</a>

Výsledek na webu

<a href="http://gbe.oxfordjournals.org/content/7/12/3484.full.pdf+html" target="_blank" >http://gbe.oxfordjournals.org/content/7/12/3484.full.pdf+html</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/gbe/evv236" target="_blank" >10.1093/gbe/evv236</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Extensive Admixture and Selective Pressure Across the Sahel Belt

Popis výsledku v původním jazyce

Genome-wide studies have the potential to reveal powerful insights into the evolution of our species. The populations of the Africa have been exposed to migrations from neighbouring regions but also to intense selective pressures imposed by diet and infectious diseases. We screened 2.5 million single nucleotide polymorphisms in 161 individuals from 13 Sahelian populations and included both nomadic and sedentary groups. We confirmed the role of the Sahel Belt as a corridor for human migrations across the African continent. Strong admixture was observed in both Central and Eastern Sahelian populations, with North Africans and Near Eastern/Arabians, respectively, but it was inexistent in Western Sahelian populations. The DARC gene region in Arabs and Nubians was enriched for African ancestry, whereas the RAB3GAP1/LCT/MCM6 region in Oromo, the TAS2R gene family in Fulani, and the ALMS1/NAT8 in Turkana and Samburu were enriched for non-African ancestry. Some genomic regions were selected across the Belt, the most striking example being the malaria-related DARC gene. Others were Western-specific (oxytocin, calcium, and heart pathways), Eastern-specific (lipid pathways), or even population-restricted (TAS2R genes in Fulani, which may reflect sexual selection).

Název v anglickém jazyce

Extensive Admixture and Selective Pressure Across the Sahel Belt

Popis výsledku anglicky

Genome-wide studies have the potential to reveal powerful insights into the evolution of our species. The populations of the Africa have been exposed to migrations from neighbouring regions but also to intense selective pressures imposed by diet and infectious diseases. We screened 2.5 million single nucleotide polymorphisms in 161 individuals from 13 Sahelian populations and included both nomadic and sedentary groups. We confirmed the role of the Sahel Belt as a corridor for human migrations across the African continent. Strong admixture was observed in both Central and Eastern Sahelian populations, with North Africans and Near Eastern/Arabians, respectively, but it was inexistent in Western Sahelian populations. The DARC gene region in Arabs and Nubians was enriched for African ancestry, whereas the RAB3GAP1/LCT/MCM6 region in Oromo, the TAS2R gene family in Fulani, and the ALMS1/NAT8 in Turkana and Samburu were enriched for non-African ancestry. Some genomic regions were selected across the Belt, the most striking example being the malaria-related DARC gene. Others were Western-specific (oxytocin, calcium, and heart pathways), Eastern-specific (lipid pathways), or even population-restricted (TAS2R genes in Fulani, which may reflect sexual selection).

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

AC - Archeologie, antropologie, etnologie

OECD FORD obor

—

Projekt

<a href="/cs/project/GA13-37998S" target="_blank" >GA13-37998S: Genetické otisky potravně produkčních systémů u lidských populací</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Genome Biology and Evolution

ISSN

1759-6653

e-ISSN

—

Svazek periodika

7

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

3484-3495

Kód UT WoS článku

000378546000017

EID výsledku v databázi Scopus

2-s2.0-84982150804