Comparison of relative toxic potencies of hydroxylated PCBs and quinones in hepatic and mammary cell lines.

Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F02%3A17023192" target="_blank" >RIV/68081707:_____/02:17023192 - isvavai.cz</a>
Výsledek na webu
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Jazyk výsledku
angličtina
Název v původním jazyce
Comparison of relative toxic potencies of hydroxylated PCBs and quinones in hepatic and mammary cell lines.
Popis výsledku v původním jazyce
A series of low-molecular-weight mono- and dihydroxylated PCBs (HO-PCBs), 2-(chlorophenyl)-1,4-benzoquinones (BQs) and 1,4-hydroquinones (HQs) were tested for their nongenotoxic potencies in several established in vitro cellular models. The data presented here show that both the low-molecular-weight PCB metabolites and the persistent HO-PCBs are capable of multiple nongenotoxic modes of action, including significant dioxin-like activity, modulation of ER-mediated activity and promotional effects associated with inhibition of intercellular communication.
Název v anglickém jazyce
Comparison of relative toxic potencies of hydroxylated PCBs and quinones in hepatic and mammary cell lines.
Popis výsledku anglicky
A series of low-molecular-weight mono- and dihydroxylated PCBs (HO-PCBs), 2-(chlorophenyl)-1,4-benzoquinones (BQs) and 1,4-hydroquinones (HQs) were tested for their nongenotoxic potencies in several established in vitro cellular models. The data presented here show that both the low-molecular-weight PCB metabolites and the persistent HO-PCBs are capable of multiple nongenotoxic modes of action, including significant dioxin-like activity, modulation of ER-mediated activity and promotional effects associated with inhibition of intercellular communication.

Rok uplatnění
2002
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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