Combined theoretical and computational study of interstrand DNA guanine-guanine cross-linking by trans-[Pt(pyridine)2] derived from the photoactivated prodrug trans,trans,trans-[Pt(N3)2(OH)2(pyridine)2]

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F12%3A00378736" target="_blank" >RIV/68081707:_____/12:00378736 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1021/ic3005745" target="_blank" >http://dx.doi.org/10.1021/ic3005745</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/ic3005745" target="_blank" >10.1021/ic3005745</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Combined theoretical and computational study of interstrand DNA guanine-guanine cross-linking by trans-[Pt(pyridine)2] derived from the photoactivated prodrug trans,trans,trans-[Pt(N3)2(OH)2(pyridine)2]

Popis výsledku v původním jazyce

Molecular modeling and extensive experimental studies were used to study DNA distortions induced by binding platinum(II)-containing fragments derived from cisplatin and a new class of photoactive platinum anticancer drugs. The major photoproduct of the novel platinum(IV) prodrug trans,trans,trans-[Pt(N3)2(OH)2(py)2] contains the trans-{Pt(py)2}2+ moiety. Using a tailored DNA sequence, experimental studies established the possibility of interstrand binding of trans-{Pt(py)2}2+ to guanine N7 positions oneach DNA strand. It was shown that such cross-links offer possibilities for specific protein-DNA interactions and suggest possible mechanisms to explain the high potency of this photoactivated complex.

Název v anglickém jazyce

Combined theoretical and computational study of interstrand DNA guanine-guanine cross-linking by trans-[Pt(pyridine)2] derived from the photoactivated prodrug trans,trans,trans-[Pt(N3)2(OH)2(pyridine)2]

Popis výsledku anglicky

Molecular modeling and extensive experimental studies were used to study DNA distortions induced by binding platinum(II)-containing fragments derived from cisplatin and a new class of photoactive platinum anticancer drugs. The major photoproduct of the novel platinum(IV) prodrug trans,trans,trans-[Pt(N3)2(OH)2(py)2] contains the trans-{Pt(py)2}2+ moiety. Using a tailored DNA sequence, experimental studies established the possibility of interstrand binding of trans-{Pt(py)2}2+ to guanine N7 positions oneach DNA strand. It was shown that such cross-links offer possibilities for specific protein-DNA interactions and suggest possible mechanisms to explain the high potency of this photoactivated complex.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

BO - Biofyzika

OECD FORD obor

—

Projekt

<a href="/cs/project/GAP301%2F10%2F0598" target="_blank" >GAP301/10/0598: Metalofarmaka odvozená od komplexů osmia, platiny a ruthenia. Od mechanistických studií k nové, účinnější chemoterapii rakoviny</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Inorganic Chemistry

ISSN

0020-1669

e-ISSN

—

Svazek periodika

51

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

6830-6841

Kód UT WoS článku

000305314500048

EID výsledku v databázi Scopus

—