The crucial role of L-arginine in macrophage activation: What you need to know about it

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F15%3A00457642" target="_blank" >RIV/68081707:_____/15:00457642 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.lfs.2015.07.012" target="_blank" >http://dx.doi.org/10.1016/j.lfs.2015.07.012</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.lfs.2015.07.012" target="_blank" >10.1016/j.lfs.2015.07.012</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The crucial role of L-arginine in macrophage activation: What you need to know about it

Popis výsledku v původním jazyce

Nowadays, it is well recognized that amino acids are powerful molecules responsible for regulatory control over fundamental cellular processes. However, our understanding of the signaling cascades involved in amino acid sensing in organisms, as well as signal initiation, is largely limited. This is also the case of semi-essential amino acid L-arginine, which has multiple metabolic fates, and it is considered as one of the most versatile amino acids. Recently, some new and important facts have been published considering the role of L-arginine in the regulation of inflammatory processes in several human and mouse models, mediated also via the regulation of macrophage activation. Therefore, this mini review focuses on the actual summarization of information about (i) L-arginine bioavailability in organism, (ii) L-arginine-dependent regulation of nitric oxide synthase expression and nitric oxide production, and importantly (iii) its role in the activation of intracellular signaling pathway

Název v anglickém jazyce

The crucial role of L-arginine in macrophage activation: What you need to know about it

Popis výsledku anglicky

Nowadays, it is well recognized that amino acids are powerful molecules responsible for regulatory control over fundamental cellular processes. However, our understanding of the signaling cascades involved in amino acid sensing in organisms, as well as signal initiation, is largely limited. This is also the case of semi-essential amino acid L-arginine, which has multiple metabolic fates, and it is considered as one of the most versatile amino acids. Recently, some new and important facts have been published considering the role of L-arginine in the regulation of inflammatory processes in several human and mouse models, mediated also via the regulation of macrophage activation. Therefore, this mini review focuses on the actual summarization of information about (i) L-arginine bioavailability in organism, (ii) L-arginine-dependent regulation of nitric oxide synthase expression and nitric oxide production, and importantly (iii) its role in the activation of intracellular signaling pathway

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

BO - Biofyzika

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Life Sciences

ISSN

0024-3205

e-ISSN

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Svazek periodika

137

Číslo periodika v rámci svazku

SEP2015

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

5

Strana od-do

44-48

Kód UT WoS článku

000361035800007

EID výsledku v databázi Scopus

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