Function of heterochromatin protein 1 during DNA repair

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F17%3A00476428" target="_blank" >RIV/68081707:_____/17:00476428 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00709-017-1090-3" target="_blank" >http://dx.doi.org/10.1007/s00709-017-1090-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00709-017-1090-3" target="_blank" >10.1007/s00709-017-1090-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Function of heterochromatin protein 1 during DNA repair

Popis výsledku v původním jazyce

This review focuses on the function of heterochromatin protein HP1 in response to DNA damage. We specifically outline the regulatory mechanisms in which HP1 and its interacting partners are involved. HP1 protein subtypes (HP1 alpha, HP1 beta, and HP1 gamma) are the main components of constitutive heterochromatin, and HP1 alpha and HP1 beta in particular are responsible for heterochromatin maintenance. The recruitment of these proteins to DNA lesions is also important from the perspective of proper DNA repair mechanisms. For example, HP1 alpha is necessary for the binding of the main DNA damage-related protein 53BP1 at DNA repair foci, which are positive not only for the HP1 alpha protein but also for the RAD51 protein, a component of DNA repair machinery. The HP1 beta protein also appears in monomeric form in DNA lesions together with the evolutionarily well-conserved protein called proliferating cell nuclear antigen (PCNA). The role of HP1 in DNA lesions is also mediated via the Kap1 transcription repressor. Taken together, these results indicate that the function of HP1 after DNA injury depends strongly on the kinetics of other DNA repair-related factors and their post-translational modifications, such as the phosphorylation of Kap-1.

Název v anglickém jazyce

Function of heterochromatin protein 1 during DNA repair

Popis výsledku anglicky

This review focuses on the function of heterochromatin protein HP1 in response to DNA damage. We specifically outline the regulatory mechanisms in which HP1 and its interacting partners are involved. HP1 protein subtypes (HP1 alpha, HP1 beta, and HP1 gamma) are the main components of constitutive heterochromatin, and HP1 alpha and HP1 beta in particular are responsible for heterochromatin maintenance. The recruitment of these proteins to DNA lesions is also important from the perspective of proper DNA repair mechanisms. For example, HP1 alpha is necessary for the binding of the main DNA damage-related protein 53BP1 at DNA repair foci, which are positive not only for the HP1 alpha protein but also for the RAD51 protein, a component of DNA repair machinery. The HP1 beta protein also appears in monomeric form in DNA lesions together with the evolutionarily well-conserved protein called proliferating cell nuclear antigen (PCNA). The role of HP1 in DNA lesions is also mediated via the Kap1 transcription repressor. Taken together, these results indicate that the function of HP1 after DNA injury depends strongly on the kinetics of other DNA repair-related factors and their post-translational modifications, such as the phosphorylation of Kap-1.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

10601 - Cell biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Protoplasma

ISSN

0033-183X

e-ISSN

—

Svazek periodika

254

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

AT - Rakouská republika

Počet stran výsledku

17

Strana od-do

1233-1240

Kód UT WoS článku

000399037400010

EID výsledku v databázi Scopus

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