Nonenzymatic Oligomerization of 3 ',5 '-Cyclic CMP Induced by Proton and UV Irradiation Hints at a Nonfastidious Origin of RNA

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F17%3A00485600" target="_blank" >RIV/68081707:_____/17:00485600 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15310/17:73584445

Výsledek na webu

<a href="http://dx.doi.org/10.1002/cbic.201700122" target="_blank" >http://dx.doi.org/10.1002/cbic.201700122</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/cbic.201700122" target="_blank" >10.1002/cbic.201700122</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Nonenzymatic Oligomerization of 3 ',5 '-Cyclic CMP Induced by Proton and UV Irradiation Hints at a Nonfastidious Origin of RNA

Popis výsledku v původním jazyce

We report that 3',5'-cyclic CMP undergoes nonenzymatic diand trimerization at 20 degrees C under dry conditions upon proton or UV irradiation. The reaction involves stacking of the cyclic monomers and subsequent polymerization through serial transphosphorylations between the stacked monomers. Proton-and UV-induced oligomerization of 3',5'-cyclic CMP demonstrates that pyrimidines-similar to purines-might also have taken part in the spontaneous generation of RNA under plausible prebiotic conditions as well as in an extraterrestrial context. The observed polymerization of naturally occurring 3',5'-cyclic nucleotides supports the possibility that the extant genetic nucleic acids might have originated by way of a straight Occamian path, starting from simple reactions between plausibly preactivated monomers.

Název v anglickém jazyce

Nonenzymatic Oligomerization of 3 ',5 '-Cyclic CMP Induced by Proton and UV Irradiation Hints at a Nonfastidious Origin of RNA

Popis výsledku anglicky

We report that 3',5'-cyclic CMP undergoes nonenzymatic diand trimerization at 20 degrees C under dry conditions upon proton or UV irradiation. The reaction involves stacking of the cyclic monomers and subsequent polymerization through serial transphosphorylations between the stacked monomers. Proton-and UV-induced oligomerization of 3',5'-cyclic CMP demonstrates that pyrimidines-similar to purines-might also have taken part in the spontaneous generation of RNA under plausible prebiotic conditions as well as in an extraterrestrial context. The observed polymerization of naturally occurring 3',5'-cyclic nucleotides supports the possibility that the extant genetic nucleic acids might have originated by way of a straight Occamian path, starting from simple reactions between plausibly preactivated monomers.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chembiochem

ISSN

1439-4227

e-ISSN

—

Svazek periodika

18

Číslo periodika v rámci svazku

15

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

9

Strana od-do

1535-1543

Kód UT WoS článku

000406932800013

EID výsledku v databázi Scopus

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