DNA Quadruple Helices in Nanotechnology

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F19%3A00510155" target="_blank" >RIV/68081707:_____/19:00510155 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubs.acs.org/doi/10.1021/acs.chemrev.8b00629" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.chemrev.8b00629</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.chemrev.8b00629" target="_blank" >10.1021/acs.chemrev.8b00629</a>

Jazyk výsledku

angličtina

Název v původním jazyce

DNA Quadruple Helices in Nanotechnology

Popis výsledku v původním jazyce

DNA has played an early and powerful role in the development of bottom up nanotechnologies, not least because of DNA's precise, predictable, and controllable properties of assembly on the nanometer scale. Watson-Crick complementarity has been used to build complex 2D and 3D architectures and design a number of nanometer-scale systems for molecular computing, transport, motors, and biosensing applications. Most of such devices are built with classical B-DNA helices and involve classical A-T/U and G-C base pairs. However, in addition to the above components underlying the iconic double helix, a number of alternative pairing schemes of nucleobases are known. This review focuses on two of these noncanonical classes of DNA helices: G-quadruplexes and the i-motif. The unique properties of these two classes of DNA helix have been utilized toward some remarkable constructions and applications: G-wires, nanostructures such as DNA origami, reconfigurable structures and nanodevices, the formation and utilization of hemin-utilizing DNAzymes, capable of generating varied outputs from biosensing nanostructures, composite nanostructures made up of DNA as well as inorganic materials, and the construction of nanocarriers that show promise for the therapeutics of diseases.

Název v anglickém jazyce

DNA Quadruple Helices in Nanotechnology

Popis výsledku anglicky

DNA has played an early and powerful role in the development of bottom up nanotechnologies, not least because of DNA's precise, predictable, and controllable properties of assembly on the nanometer scale. Watson-Crick complementarity has been used to build complex 2D and 3D architectures and design a number of nanometer-scale systems for molecular computing, transport, motors, and biosensing applications. Most of such devices are built with classical B-DNA helices and involve classical A-T/U and G-C base pairs. However, in addition to the above components underlying the iconic double helix, a number of alternative pairing schemes of nucleobases are known. This review focuses on two of these noncanonical classes of DNA helices: G-quadruplexes and the i-motif. The unique properties of these two classes of DNA helix have been utilized toward some remarkable constructions and applications: G-wires, nanostructures such as DNA origami, reconfigurable structures and nanodevices, the formation and utilization of hemin-utilizing DNAzymes, capable of generating varied outputs from biosensing nanostructures, composite nanostructures made up of DNA as well as inorganic materials, and the construction of nanocarriers that show promise for the therapeutics of diseases.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

<a href="/cs/project/EF15_003%2F0000477" target="_blank" >EF15_003/0000477: Strukturní gymnastika nukleových kyselin: od molekulárních principů přes biologické funkce k terapeutickým cílům.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemical Reviews

ISSN

0009-2665

e-ISSN

—

Svazek periodika

119

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

36

Strana od-do

6290-6325

Kód UT WoS článku

000469288500003

EID výsledku v databázi Scopus

—