Electrochemical reduction and oxidation of eight unnatural 2 '-deoxynucleosides at a pyrolytic graphite electrode

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F20%3A00536121" target="_blank" >RIV/68081707:_____/20:00536121 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14740/20:00118306

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0013468620316030?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0013468620316030?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.electacta.2020.137210" target="_blank" >10.1016/j.electacta.2020.137210</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Electrochemical reduction and oxidation of eight unnatural 2 '-deoxynucleosides at a pyrolytic graphite electrode

Popis výsledku v původním jazyce

Recently we showed the reduction and oxidation of six natural 2'-deoxynucleosides in the presence of the ambient oxygen using the very broad potential window of a pyrolytic graphite electrode (PGE). Using the same procedure, 2'-deoxynucleoside analogs (dNs) that are parts of an artificially expanded genetic information system (AEGIS) were analyzed. Seven of the eight tested AEGIS dNs provided specific signals (voltammetric redox peaks). These signals, described here for the first time, will be used in future work to analyze DNA built from expanded genetic alphabets, helping to further develop AEGIS technology and its applications. Comparison of the electrochemical behavior of unnatural dNs with the previously documented behaviors of natural dNs also provides insights into the mechanisms of their respective redox processes. (C) 2020 Elsevier Ltd. All rights reserved.

Název v anglickém jazyce

Electrochemical reduction and oxidation of eight unnatural 2 '-deoxynucleosides at a pyrolytic graphite electrode

Popis výsledku anglicky

Recently we showed the reduction and oxidation of six natural 2'-deoxynucleosides in the presence of the ambient oxygen using the very broad potential window of a pyrolytic graphite electrode (PGE). Using the same procedure, 2'-deoxynucleoside analogs (dNs) that are parts of an artificially expanded genetic information system (AEGIS) were analyzed. Seven of the eight tested AEGIS dNs provided specific signals (voltammetric redox peaks). These signals, described here for the first time, will be used in future work to analyze DNA built from expanded genetic alphabets, helping to further develop AEGIS technology and its applications. Comparison of the electrochemical behavior of unnatural dNs with the previously documented behaviors of natural dNs also provides insights into the mechanisms of their respective redox processes. (C) 2020 Elsevier Ltd. All rights reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Electrochimica acta

ISSN

0013-4686

e-ISSN

—

Svazek periodika

362

Číslo periodika v rámci svazku

2020

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

137210

Kód UT WoS článku

000582869700067

EID výsledku v databázi Scopus

2-s2.0-85092252648