WNT5B in Physiology and Disease
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F21%3A00555638" target="_blank" >RIV/68081707:_____/21:00555638 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216224:14310/21:00121666
Výsledek na webu
<a href="https://www.frontiersin.org/articles/10.3389/fcell.2021.667581/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fcell.2021.667581/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fcell.2021.667581" target="_blank" >10.3389/fcell.2021.667581</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
WNT5B in Physiology and Disease
Popis výsledku v původním jazyce
WNT5B, a member of the WNT family of proteins that is closely related to WNT5A, is required for cell migration, cell proliferation, or cell differentiation in many cell types. WNT5B signals through the non-canonical beta-catenin-independent signaling pathway and often functions as an antagonist of canonical WNT signaling. Although WNT5B has a high amino acid identity with WNT5A and is often assumed to have similar activities, WNT5B often exhibits unique expression patterns and functions. Here, we describe the distinct effects and mechanisms of WNT5B on development, bone, adipose tissue, cardiac tissue, the nervous system, the mammary gland, the lung and hematopoietic cells, compared to WNT5A. We also highlight aberrances in non-canonical WNT5B signaling contributing to diseases such as osteoarthritis, osteoporosis, obesity, type 2 diabetes mellitus, neuropathology, and chronic diseases associated with aging, as well as various cancers.
Název v anglickém jazyce
WNT5B in Physiology and Disease
Popis výsledku anglicky
WNT5B, a member of the WNT family of proteins that is closely related to WNT5A, is required for cell migration, cell proliferation, or cell differentiation in many cell types. WNT5B signals through the non-canonical beta-catenin-independent signaling pathway and often functions as an antagonist of canonical WNT signaling. Although WNT5B has a high amino acid identity with WNT5A and is often assumed to have similar activities, WNT5B often exhibits unique expression patterns and functions. Here, we describe the distinct effects and mechanisms of WNT5B on development, bone, adipose tissue, cardiac tissue, the nervous system, the mammary gland, the lung and hematopoietic cells, compared to WNT5A. We also highlight aberrances in non-canonical WNT5B signaling contributing to diseases such as osteoarthritis, osteoporosis, obesity, type 2 diabetes mellitus, neuropathology, and chronic diseases associated with aging, as well as various cancers.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10601 - Cell biology
Návaznosti výsledku
Projekt
<a href="/cs/project/EF16_025%2F0007381" target="_blank" >EF16_025/0007381: Preklinická progrese nových organických sloučenin s cílenou biologickou aktivitou</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2021
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Frontiers in Cell and Developmental Biology
ISSN
2296-634X
e-ISSN
2296-634X
Svazek periodika
09
Číslo periodika v rámci svazku
MAY 4 2021
Stát vydavatele periodika
CH - Švýcarská konfederace
Počet stran výsledku
20
Strana od-do
667581
Kód UT WoS článku
000651394300001
EID výsledku v databázi Scopus
2-s2.0-85106051215