Coupling BODIPY with nitrogen-doped graphene quantum dots to address the water solubility of photosensitizers

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F22%3A00558373" target="_blank" >RIV/68081707:_____/22:00558373 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216305:26620/22:PU144986 RIV/00216224:14310/22:00126190

Výsledek na webu

<a href="https://pubs.rsc.org/en/content/articlelanding/2022/QM/D2QM00200K" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2022/QM/D2QM00200K</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/d2qm00200k" target="_blank" >10.1039/d2qm00200k</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Coupling BODIPY with nitrogen-doped graphene quantum dots to address the water solubility of photosensitizers

Popis výsledku v původním jazyce

The potential of photodynamic therapy (PDT) applications is based primarily on the selection of suitable photosensitizers (PSs). However, highly efficient PSs producing singlet oxygen and other reactive oxygen species (ROS) often have poor water solubility and tend to aggregate in biological media. The most common alternative strategy to address the solubility of PSs is based on difficult-to-control encapsulation or conjugation to liposomes, micelles, or other nanoparticles via surface non-covalent interactions. Covalent functionalization remains relatively unexplored for common PSs. Here, we report a strategy to use highly efficient but poorly water-soluble BODIPY PSs connected to the surface of nitrogen-doped graphene quantum dots (NGQDs) through controlled covalent functionalization. These NGQD-BODIPY PSs do not aggregate in aqueous solutions and generate ROS upon irradiation with visible light, with singlet-oxygen production quantum yields up to 83%. In vitro fluorescence bioimaging was used to confirm that the PSs reside mostly in the cytoplasmic region of human cervical cancer cells (HeLa), and the system reduced the cell viability by similar to 85% upon irradiation.

Název v anglickém jazyce

Coupling BODIPY with nitrogen-doped graphene quantum dots to address the water solubility of photosensitizers

Popis výsledku anglicky

The potential of photodynamic therapy (PDT) applications is based primarily on the selection of suitable photosensitizers (PSs). However, highly efficient PSs producing singlet oxygen and other reactive oxygen species (ROS) often have poor water solubility and tend to aggregate in biological media. The most common alternative strategy to address the solubility of PSs is based on difficult-to-control encapsulation or conjugation to liposomes, micelles, or other nanoparticles via surface non-covalent interactions. Covalent functionalization remains relatively unexplored for common PSs. Here, we report a strategy to use highly efficient but poorly water-soluble BODIPY PSs connected to the surface of nitrogen-doped graphene quantum dots (NGQDs) through controlled covalent functionalization. These NGQD-BODIPY PSs do not aggregate in aqueous solutions and generate ROS upon irradiation with visible light, with singlet-oxygen production quantum yields up to 83%. In vitro fluorescence bioimaging was used to confirm that the PSs reside mostly in the cytoplasmic region of human cervical cancer cells (HeLa), and the system reduced the cell viability by similar to 85% upon irradiation.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10700 - Other natural sciences

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Materials Chemistry Frontiers

ISSN

2052-1537

e-ISSN

2052-1537

Svazek periodika

6

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

1719-1726

Kód UT WoS článku

000802645400001

EID výsledku v databázi Scopus

2-s2.0-85131816322