Exploring Sequence Space to Design Controllable G-Quadruplex Topology Switches

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F22%3A00563710" target="_blank" >RIV/68081707:_____/22:00563710 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15640/22:73618759

Výsledek na webu

<a href="https://www.chinesechemsoc.org/doi/10.31635/ccschem.021.202101357" target="_blank" >https://www.chinesechemsoc.org/doi/10.31635/ccschem.021.202101357</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.31635/ccschem.021.202101357" target="_blank" >10.31635/ccschem.021.202101357</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Exploring Sequence Space to Design Controllable G-Quadruplex Topology Switches

Popis výsledku v původním jazyce

As nonclassical nucleic acid structures, G-quadruplexes (G4s) not only play important roles in gene regulation and stability maintenance, but are also widely used in nanotechnology. Structural diversity is one of the main factors explaining the popularity of G4s, but a comprehensive and integrated study of different factors determining G4 structural versatility is currently lacking. Herein, starting from a common G4 sequence, (G3T)3G3, as the parent chain, and then taking advantage of G4 versatility, we present a variety of strategies to control G4 structure, based on the regulation of loop length and flanking sequences, cation (type and concentration), and molecular crowding. These strategies allow us to con-vert the G4 topology from parallel to hybrid, to antiparallel, and then back to parallel. Such structural diversity reveals the coding regulation ability of G4 structures, with potential applications in nanotechnology.

Název v anglickém jazyce

Exploring Sequence Space to Design Controllable G-Quadruplex Topology Switches

Popis výsledku anglicky

As nonclassical nucleic acid structures, G-quadruplexes (G4s) not only play important roles in gene regulation and stability maintenance, but are also widely used in nanotechnology. Structural diversity is one of the main factors explaining the popularity of G4s, but a comprehensive and integrated study of different factors determining G4 structural versatility is currently lacking. Herein, starting from a common G4 sequence, (G3T)3G3, as the parent chain, and then taking advantage of G4 versatility, we present a variety of strategies to control G4 structure, based on the regulation of loop length and flanking sequences, cation (type and concentration), and molecular crowding. These strategies allow us to con-vert the G4 topology from parallel to hybrid, to antiparallel, and then back to parallel. Such structural diversity reveals the coding regulation ability of G4 structures, with potential applications in nanotechnology.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

CCS CHEMISTRY

ISSN

2096-5745

e-ISSN

2096-5745

Svazek periodika

4

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

CN - Čínská lidová republika

Počet stran výsledku

15

Strana od-do

3036-3050

Kód UT WoS článku

000871904500004

EID výsledku v databázi Scopus

2-s2.0-85137921193