Telomeres expand sphere of influence: emerging molecular impact of telomeres in non-telomeric functions

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F23%3A00569311" target="_blank" >RIV/68081707:_____/23:00569311 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0168952522002505?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0168952522002505?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.tig.2022.10.002" target="_blank" >10.1016/j.tig.2022.10.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Telomeres expand sphere of influence: emerging molecular impact of telomeres in non-telomeric functions

Popis výsledku v původním jazyce

Although the impact of telomeres on physiology stands well established, a question remains: how do telomeres impact cellular functions at a molecular level? This is because current understanding limits the influence of telomeres to adjacent subtelomeric regions despite the wide-ranging impact of telomeres. Emerging work in two distinct aspects offers opportunities to bridge this gap. First, telomere-binding factors were found with non-telomeric functions. Second, locally induced DNA secondary structures called G-quadruplexes are notably abundant in telomeres, and gene regulatory regions genome wide. Many telomeric factors bind to G-quadruplexes for non-telomeric functions. Here we discuss a more general model of how telomeres impact the non-telomeric genome through factors that associate at telomeres and genome wide and influence cell-intrinsic functions, particularly aging, cancer, and pluripotency.

Název v anglickém jazyce

Telomeres expand sphere of influence: emerging molecular impact of telomeres in non-telomeric functions

Popis výsledku anglicky

Although the impact of telomeres on physiology stands well established, a question remains: how do telomeres impact cellular functions at a molecular level? This is because current understanding limits the influence of telomeres to adjacent subtelomeric regions despite the wide-ranging impact of telomeres. Emerging work in two distinct aspects offers opportunities to bridge this gap. First, telomere-binding factors were found with non-telomeric functions. Second, locally induced DNA secondary structures called G-quadruplexes are notably abundant in telomeres, and gene regulatory regions genome wide. Many telomeric factors bind to G-quadruplexes for non-telomeric functions. Here we discuss a more general model of how telomeres impact the non-telomeric genome through factors that associate at telomeres and genome wide and influence cell-intrinsic functions, particularly aging, cancer, and pluripotency.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10603 - Genetics and heredity (medical genetics to be 3)

Projekt

<a href="/cs/project/EF15_003%2F0000477" target="_blank" >EF15_003/0000477: Strukturní gymnastika nukleových kyselin: od molekulárních principů přes biologické funkce k terapeutickým cílům.</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Trends in Genetics

ISSN

0168-9525

e-ISSN

1362-4555

Svazek periodika

39

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

15

Strana od-do

59-73

Kód UT WoS článku

000913243000007

EID výsledku v databázi Scopus

2-s2.0-85142173903