TeloBase: a community-curated database of telomere sequences across the tree of life
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F24%3A00600734" target="_blank" >RIV/68081707:_____/24:00600734 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216224:14740/24:00135437
Výsledek na webu
<a href="https://academic.oup.com/nar/article/52/D1/D311/7246534?login=true" target="_blank" >https://academic.oup.com/nar/article/52/D1/D311/7246534?login=true</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/nar/gkad672" target="_blank" >10.1093/nar/gkad672</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
TeloBase: a community-curated database of telomere sequences across the tree of life
Popis výsledku v původním jazyce
Discoveries over the recent decade have demonstrated the unexpected diversity of telomere DNA motifs in nature. Ho we ver, currently available resources, Telomerase database' and Plant rDNA database', contain just fragments of all relevant literature published over decades of telomere research as they have a different primary focus and limited updates. To fill this gap, we gathered data about telomere DNA sequences from a thorough literature screen as well as by anal ysing publicly available NGS data, and we created TeloBase (http://cfb.ceitec.muni.cz/ telobase/) as a comprehensive database of information about telomere motif diversity. TeloBase is supplemented by internal taxonomy utilizing popular on-line taxonomic resources that enables in-house data filtration and graphical visualisation of telomere DNA evolutionary dynamics in the form of heat tree plots. TeloBase avoids overreliance on administrators for future data updates by having a simple form and community-curation system for application and approval, respectively, of new telomere sequences by users, which should ensure timeliness of the database and topicality .To demonstrate TeloBase utility, we examined telomere motif diversity in species from the fungal genus Aspergillus, and discovered (TTTATTAGGG)n sequence as a putative telomere motif in the plant family Chrysobalanaceae. This was bioinformatically confirmed by analysing template regions of identified telomerase RNAs.
Název v anglickém jazyce
TeloBase: a community-curated database of telomere sequences across the tree of life
Popis výsledku anglicky
Discoveries over the recent decade have demonstrated the unexpected diversity of telomere DNA motifs in nature. Ho we ver, currently available resources, Telomerase database' and Plant rDNA database', contain just fragments of all relevant literature published over decades of telomere research as they have a different primary focus and limited updates. To fill this gap, we gathered data about telomere DNA sequences from a thorough literature screen as well as by anal ysing publicly available NGS data, and we created TeloBase (http://cfb.ceitec.muni.cz/ telobase/) as a comprehensive database of information about telomere motif diversity. TeloBase is supplemented by internal taxonomy utilizing popular on-line taxonomic resources that enables in-house data filtration and graphical visualisation of telomere DNA evolutionary dynamics in the form of heat tree plots. TeloBase avoids overreliance on administrators for future data updates by having a simple form and community-curation system for application and approval, respectively, of new telomere sequences by users, which should ensure timeliness of the database and topicality .To demonstrate TeloBase utility, we examined telomere motif diversity in species from the fungal genus Aspergillus, and discovered (TTTATTAGGG)n sequence as a putative telomere motif in the plant family Chrysobalanaceae. This was bioinformatically confirmed by analysing template regions of identified telomerase RNAs.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10608 - Biochemistry and molecular biology
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2024
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Nucleic Acids Research
ISSN
0305-1048
e-ISSN
1362-4962
Svazek periodika
52
Číslo periodika v rámci svazku
D1
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
11
Strana od-do
"D311"-"D321"
Kód UT WoS článku
001051997800001
EID výsledku v databázi Scopus
2-s2.0-85177656943