Deciphering the intermolecular interactions between G-quadruplex (G4)-forming sequences

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F25%3A00643357" target="_blank" >RIV/68081707:_____/25:00643357 - isvavai.cz</a>

Výsledek na webu

<a href="https://academic.oup.com/nar/article/53/22/gkaf1288/8363854" target="_blank" >https://academic.oup.com/nar/article/53/22/gkaf1288/8363854</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/nar/gkaf1288" target="_blank" >10.1093/nar/gkaf1288</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Deciphering the intermolecular interactions between G-quadruplex (G4)-forming sequences

Popis výsledku v původním jazyce

Interactions between biomolecules govern cellular biology. While protein/protein and protein/nucleic acid (DNA, RNA) interactions-and, to a lesser extent, RNA/RNA and RNA/DNA interactions-have been extensively described, a question remains as to whether and how non-canonical DNA structures might interact with each other. This is of particular interest for guanine (G)-rich sequences that can fold into G-quadruplex (G4) structures: Individual G4s are currently studied for their involvement in a myriad of cellular events (mostly pertaining to the control of gene expression), and, more recently, the interactions between two G4s have been scrutinized as being part of a novel gene expression regulatory mechanism involving chromatin remodeling through G4-mediated loop formation. The question that needs to be answered is whether G4s or their corresponding G-rich sequences are involved. We present here a series of results collected using a combination of sequences, experimental conditions, and techniques, which led us to the conclusion that G4/G4 intermolecular interactions are mostly governed by primary sequence interactions in vitro.

Název v anglickém jazyce

Deciphering the intermolecular interactions between G-quadruplex (G4)-forming sequences

Popis výsledku anglicky

Interactions between biomolecules govern cellular biology. While protein/protein and protein/nucleic acid (DNA, RNA) interactions-and, to a lesser extent, RNA/RNA and RNA/DNA interactions-have been extensively described, a question remains as to whether and how non-canonical DNA structures might interact with each other. This is of particular interest for guanine (G)-rich sequences that can fold into G-quadruplex (G4) structures: Individual G4s are currently studied for their involvement in a myriad of cellular events (mostly pertaining to the control of gene expression), and, more recently, the interactions between two G4s have been scrutinized as being part of a novel gene expression regulatory mechanism involving chromatin remodeling through G4-mediated loop formation. The question that needs to be answered is whether G4s or their corresponding G-rich sequences are involved. We present here a series of results collected using a combination of sequences, experimental conditions, and techniques, which led us to the conclusion that G4/G4 intermolecular interactions are mostly governed by primary sequence interactions in vitro.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nucleic Acids Research

ISSN

0305-1048

e-ISSN

1362-4962

Svazek periodika

53

Číslo periodika v rámci svazku

22

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

gkaf1288

Kód UT WoS článku

001629554600001

EID výsledku v databázi Scopus

2-s2.0-105023764936