Electrophoretic Deposition and Characterization ofnFunctional Coatings Based on an AntibacterialnGallium (III)‐Chitosan Complex

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081723%3A_____%2F20%3A00524683" target="_blank" >RIV/68081723:_____/20:00524683 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.mdpi.com/2079-6412/10/5/483" target="_blank" >https://www.mdpi.com/2079-6412/10/5/483</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/coatings10050483" target="_blank" >10.3390/coatings10050483</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Electrophoretic Deposition and Characterization ofnFunctional Coatings Based on an AntibacterialnGallium (III)‐Chitosan Complex

Popis výsledku v původním jazyce

Despite their broad biomedical applications in orthopedics and dentistry, metallicnimplants are still associated with failures due to their lack of surface biofunctionality, leading tonprosthesis‐related microbial infections. In order to address this issue, the current study focuses onnthe fabrication and characterization of a novel type of antibacterial coating based on gallium (III)‐nchitosan (Ga (III)‐CS) complex layers deposited on metallic substrates via electrophoretic depositionn(EPD). Aiming for the production of homogeneous and monophasic coatings, a two step‐procedurenwas applied: the first step involved the synthesis of the Ga (III)‐CS complex, followed by EPD fromnsuitable solutions in an acetic acid–aqueous solvent. The influence of Ga (III) concentration on thenstability of the suspensions was evaluated in terms of zeta potential. Fourier transform infraredn(FTIR) and energy dispersive X‐ray (EDX) spectroscopic analyses indicated the chelation of CS withnGa (III) within the coatings, while scanning electron microscopy (SEM) confirmed that no additionalnmetallic gallium deposited during EPD. Furthermore, the results demonstrated that the wettability,nmechanical properties, swelling ability, and enzymatic degradation of the coatings were affected bynthe quantity of Ga (III) ions. Colony forming unit (CFU) tests showed a strong synergistic effectnbetween CS and Ga (III) in inhibiting Escherichia coli strain growth compared to control CS samples.nAn in vitro study with MG‐63 cells showed that Ga (III)‐containing coatings were not toxic after 24 h ofnincubation.

Název v anglickém jazyce

Electrophoretic Deposition and Characterization ofnFunctional Coatings Based on an AntibacterialnGallium (III)‐Chitosan Complex

Popis výsledku anglicky

Despite their broad biomedical applications in orthopedics and dentistry, metallicnimplants are still associated with failures due to their lack of surface biofunctionality, leading tonprosthesis‐related microbial infections. In order to address this issue, the current study focuses onnthe fabrication and characterization of a novel type of antibacterial coating based on gallium (III)‐nchitosan (Ga (III)‐CS) complex layers deposited on metallic substrates via electrophoretic depositionn(EPD). Aiming for the production of homogeneous and monophasic coatings, a two step‐procedurenwas applied: the first step involved the synthesis of the Ga (III)‐CS complex, followed by EPD fromnsuitable solutions in an acetic acid–aqueous solvent. The influence of Ga (III) concentration on thenstability of the suspensions was evaluated in terms of zeta potential. Fourier transform infraredn(FTIR) and energy dispersive X‐ray (EDX) spectroscopic analyses indicated the chelation of CS withnGa (III) within the coatings, while scanning electron microscopy (SEM) confirmed that no additionalnmetallic gallium deposited during EPD. Furthermore, the results demonstrated that the wettability,nmechanical properties, swelling ability, and enzymatic degradation of the coatings were affected bynthe quantity of Ga (III) ions. Colony forming unit (CFU) tests showed a strong synergistic effectnbetween CS and Ga (III) in inhibiting Escherichia coli strain growth compared to control CS samples.nAn in vitro study with MG‐63 cells showed that Ga (III)‐containing coatings were not toxic after 24 h ofnincubation.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20506 - Coating and films

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Coatings

ISSN

2079-6412

e-ISSN

—

Svazek periodika

10

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

20

Strana od-do

483

Kód UT WoS článku

000541770900061

EID výsledku v databázi Scopus

2-s2.0-85086678138