Effect of Ni ion release on the cells in contact with NiTi alloys

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081723%3A_____%2F20%3A00534086" target="_blank" >RIV/68081723:_____/20:00534086 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/20:00114179

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s11356-019-07506-8" target="_blank" >https://link.springer.com/article/10.1007/s11356-019-07506-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11356-019-07506-8" target="_blank" >10.1007/s11356-019-07506-8</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of Ni ion release on the cells in contact with NiTi alloys

Popis výsledku v původním jazyce

Nickel-titanium alloys have been used in medical applications for several years, however, biocompatibility of the materialnremains controversial. In the present study, the human umbilical vein endothelial cells (HUVEC) were cultured in contact withnthe nitinol used in two different heat treatment surface modifications—helium and hydrogen. The amount of Ni ions releasednfrom these alloys in contact with HUVEC was measured in media and in the cells by ICP-MS. An increased release of Ni ionsnwas detected in He alloy compared with H2 alloy modification with an elevation with the metal exposition duration (24 h vs.n72 h). The cells contained the Ni ions in both selected alloy modifications with the lower levels in H2 alloys. To evaluate thenpotential of multiple metal applications, similar values were observed in media and in cell suspension for all surface modificationncombinations. The model analysis of effect of metal ion release on distant cells in the body showed that the concentration isninterestingly similar to concentrations in cells in direct contact with the metal alloy. The cells are able to regulate the concentrationnof Ni ions within the cell. According to our best knowledge, the study for the first time describes the presence of Ni ions releasednfrom nitinol directly in the cells. In the case of the H2 modification, the lowest levels of Ni ions were detected both in medium andnin the cells, which likely increases the biocompatibility of the nitinol alloy.

Název v anglickém jazyce

Effect of Ni ion release on the cells in contact with NiTi alloys

Popis výsledku anglicky

Nickel-titanium alloys have been used in medical applications for several years, however, biocompatibility of the materialnremains controversial. In the present study, the human umbilical vein endothelial cells (HUVEC) were cultured in contact withnthe nitinol used in two different heat treatment surface modifications—helium and hydrogen. The amount of Ni ions releasednfrom these alloys in contact with HUVEC was measured in media and in the cells by ICP-MS. An increased release of Ni ionsnwas detected in He alloy compared with H2 alloy modification with an elevation with the metal exposition duration (24 h vs.n72 h). The cells contained the Ni ions in both selected alloy modifications with the lower levels in H2 alloys. To evaluate thenpotential of multiple metal applications, similar values were observed in media and in cell suspension for all surface modificationncombinations. The model analysis of effect of metal ion release on distant cells in the body showed that the concentration isninterestingly similar to concentrations in cells in direct contact with the metal alloy. The cells are able to regulate the concentrationnof Ni ions within the cell. According to our best knowledge, the study for the first time describes the presence of Ni ions releasednfrom nitinol directly in the cells. In the case of the H2 modification, the lowest levels of Ni ions were detected both in medium andnin the cells, which likely increases the biocompatibility of the nitinol alloy.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20802 - Bioremediation, diagnostic biotechnologies (DNA chips and biosensing devices) in environmental management

Projekt

<a href="/cs/project/GA15-16336S" target="_blank" >GA15-16336S: Intersticiální příměsi v tvarově-paměťových slitinách na bázi NiTi</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Environmental Science and Pollution Research

ISSN

0944-1344

e-ISSN

—

Svazek periodika

27

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

9

Strana od-do

7934-7942

Kód UT WoS článku

000517084600014

EID výsledku v databázi Scopus

2-s2.0-85077201115