Cognitive task-related functional connectivity alterations in temporal lobe epilepsy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F20%3A00535328" target="_blank" >RIV/68081731:_____/20:00535328 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00159816:_____/20:00073360 RIV/00216224:14740/20:00118636

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/abs/pii/S1525505020305886" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S1525505020305886</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.yebeh.2020.107409" target="_blank" >10.1016/j.yebeh.2020.107409</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cognitive task-related functional connectivity alterations in temporal lobe epilepsy

Popis výsledku v původním jazyce

We investigated cognitive task-related functional connectivity (FC) in patients with temporal lobe epilepsy (TLE). Using a visual three-stimulus paradigm (VTSP), we studied cognitive large-scale networks and the impact of TLE on connectivity outside the temporal lobe. Methods: High-density electroencephalography (EEG) was recorded during the paradigm from nineteen patients with epilepsy with hippocampal sclerosis (HS) and ten healthy controls (HCs). Scalp data were reconstructed into the source space, and FC was computed. Correlating with the neuropsychological data, possible compensatory mechanisms were investigated. Results: Significant changes were found in the FC of regions outside the epileptogenic network, particularly in the attentional network. These changes were more widespread in left TLE (LTLE). There were no significant differences in task performance (accuracy, time response) in comparison with HCs, implying that there must be some mechanism reducing the impact of connectivity changes on brain functions. When correlated with neuropsychological data, we found stronger compensatory mechanisms in right TLE (RTLE). Significance: Our findings confirm the hypothesis that LTLE is the more pervasive form of the disease. Even though the network alterations in TLE are severe, some mechanisms reduce the impact of epilepsy on cognitive functions, these mechanisms are more potent in RTLE. We also suggest that there are maladaptive mechanisms in LTLE.

Název v anglickém jazyce

Cognitive task-related functional connectivity alterations in temporal lobe epilepsy

Popis výsledku anglicky

We investigated cognitive task-related functional connectivity (FC) in patients with temporal lobe epilepsy (TLE). Using a visual three-stimulus paradigm (VTSP), we studied cognitive large-scale networks and the impact of TLE on connectivity outside the temporal lobe. Methods: High-density electroencephalography (EEG) was recorded during the paradigm from nineteen patients with epilepsy with hippocampal sclerosis (HS) and ten healthy controls (HCs). Scalp data were reconstructed into the source space, and FC was computed. Correlating with the neuropsychological data, possible compensatory mechanisms were investigated. Results: Significant changes were found in the FC of regions outside the epileptogenic network, particularly in the attentional network. These changes were more widespread in left TLE (LTLE). There were no significant differences in task performance (accuracy, time response) in comparison with HCs, implying that there must be some mechanism reducing the impact of connectivity changes on brain functions. When correlated with neuropsychological data, we found stronger compensatory mechanisms in right TLE (RTLE). Significance: Our findings confirm the hypothesis that LTLE is the more pervasive form of the disease. Even though the network alterations in TLE are severe, some mechanisms reduce the impact of epilepsy on cognitive functions, these mechanisms are more potent in RTLE. We also suggest that there are maladaptive mechanisms in LTLE.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20601 - Medical engineering

Projekt

<a href="/cs/project/NV17-32292A" target="_blank" >NV17-32292A: Detekce léze u nelezionální epilepsie s využitím multimodálního zobrazování</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Epilepsy and Behavior

ISSN

1525-5050

e-ISSN

—

Svazek periodika

112

Číslo periodika v rámci svazku

NOV

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

107409

Kód UT WoS článku

000588004200075

EID výsledku v databázi Scopus

2-s2.0-85090362160