Memory retrieval in temporal lobe epilepsy is related to functional segregation of the mesiotemporal structures

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00074662" target="_blank" >RIV/00159816:_____/21:00074662 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14740/21:00120192

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/abs/pii/S1525505021004571?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S1525505021004571?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.yebeh.2021.108196" target="_blank" >10.1016/j.yebeh.2021.108196</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Memory retrieval in temporal lobe epilepsy is related to functional segregation of the mesiotemporal structures

Popis výsledku v původním jazyce

Objective: We analyzed the impact of temporal lobe epilepsy (TLE) with hippocampal sclerosis (HS) on functional connectivity (FC) between mesiotemporal structures. Functional connectivity modifications related to word retrieval were investigated. Methods: High-density EEG of 21 patients with TLE with HS (12 left TLE and 9 right TLE) and 10 healthy controls (HCs) were recorded during a verbal subsequent memory paradigm. Electroencephalography data were reconstructed into the source space and FC was calculated from the source activity of regions of interest. Results: A significant decrease in FC between the right-and left-sided mesiotemporal structures in TLE was observed. The decrease was significant only with words that were correctly recognized. The decrease in interhemispheric FC between mesiotemporal structures was found in the 8-to 20-Hz frequency range in both left and right TLE. Significance: The decreased FC between the mesiotemporal structures in TLE is a condition for successful performance of a memory retrieval task. The successful memory retrieval in TLE is related to functional segregation of lesional from nonlesional mesiotemporal structures. This decrease was absent in non successful responses. (c) 2021 Elsevier Inc. All rights reserved.

Název v anglickém jazyce

Memory retrieval in temporal lobe epilepsy is related to functional segregation of the mesiotemporal structures

Popis výsledku anglicky

Objective: We analyzed the impact of temporal lobe epilepsy (TLE) with hippocampal sclerosis (HS) on functional connectivity (FC) between mesiotemporal structures. Functional connectivity modifications related to word retrieval were investigated. Methods: High-density EEG of 21 patients with TLE with HS (12 left TLE and 9 right TLE) and 10 healthy controls (HCs) were recorded during a verbal subsequent memory paradigm. Electroencephalography data were reconstructed into the source space and FC was calculated from the source activity of regions of interest. Results: A significant decrease in FC between the right-and left-sided mesiotemporal structures in TLE was observed. The decrease was significant only with words that were correctly recognized. The decrease in interhemispheric FC between mesiotemporal structures was found in the 8-to 20-Hz frequency range in both left and right TLE. Significance: The decreased FC between the mesiotemporal structures in TLE is a condition for successful performance of a memory retrieval task. The successful memory retrieval in TLE is related to functional segregation of lesional from nonlesional mesiotemporal structures. This decrease was absent in non successful responses. (c) 2021 Elsevier Inc. All rights reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

<a href="/cs/project/NU21-04-00254" target="_blank" >NU21-04-00254: Detekce zóny počátku záchvatu u multi-lezionální epilepsie s užitím multimodálního neurozobrazování</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Epilepsy &amp; Behavior

ISSN

1525-5050

e-ISSN

—

Svazek periodika

122

Číslo periodika v rámci svazku

SEP 2021

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

108196

Kód UT WoS článku

000693182100013

EID výsledku v databázi Scopus

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