Suboptimal response to STN-DBS in Parkinson's disease can be identified via reaction times in a motor cognitive paradigm

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F20%3A00535623" target="_blank" >RIV/68081731:_____/20:00535623 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14740/20:00118223 RIV/00159816:_____/20:00073206

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s00702-020-02254-3" target="_blank" >https://link.springer.com/article/10.1007/s00702-020-02254-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00702-020-02254-3" target="_blank" >10.1007/s00702-020-02254-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Suboptimal response to STN-DBS in Parkinson's disease can be identified via reaction times in a motor cognitive paradigm

Popis výsledku v původním jazyce

Although deep brain stimulation of the subthalamic nucleus (STN-DBS) in Parkinson's disease (PD) is generally a successful therapy, adverse events and insufficient clinical effect can complicate the treatment in some patients. We studied clinical parameters and cortical oscillations related to STN-DBS to identify patients with suboptimal responses. High-density EEG was recorded during a visual oddball three-stimuli paradigm in DBS off and on conditions in 32 PD patients with STN-DBS. Pre-processed data were reconstructed into the source space and the time-frequency analysis was evaluated. We identified a subgroup of six patients with longer reaction times (RT) during the DBS on state than in the DBS off state after target stimuli. These subjects had lower motor responsiveness to DBS and decreased memory test results compared to the other subjects. Moreover, the alpha and beta power decrease (event-related desynchronizations, ERD), known as an activation correlate linked to motor and cognitive processing, was also reduced in the DBS on condition in these patients. A subgroup of PD patients with a suboptimal response to STN-DBS was identified. Evaluation of RT could potentially serve as a biomarker for responsiveness to STN-DBS.

Název v anglickém jazyce

Suboptimal response to STN-DBS in Parkinson's disease can be identified via reaction times in a motor cognitive paradigm

Popis výsledku anglicky

Although deep brain stimulation of the subthalamic nucleus (STN-DBS) in Parkinson's disease (PD) is generally a successful therapy, adverse events and insufficient clinical effect can complicate the treatment in some patients. We studied clinical parameters and cortical oscillations related to STN-DBS to identify patients with suboptimal responses. High-density EEG was recorded during a visual oddball three-stimuli paradigm in DBS off and on conditions in 32 PD patients with STN-DBS. Pre-processed data were reconstructed into the source space and the time-frequency analysis was evaluated. We identified a subgroup of six patients with longer reaction times (RT) during the DBS on state than in the DBS off state after target stimuli. These subjects had lower motor responsiveness to DBS and decreased memory test results compared to the other subjects. Moreover, the alpha and beta power decrease (event-related desynchronizations, ERD), known as an activation correlate linked to motor and cognitive processing, was also reduced in the DBS on condition in these patients. A subgroup of PD patients with a suboptimal response to STN-DBS was identified. Evaluation of RT could potentially serve as a biomarker for responsiveness to STN-DBS.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20601 - Medical engineering

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Neural Transmission

ISSN

0300-9564

e-ISSN

—

Svazek periodika

127

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

AT - Rakouská republika

Počet stran výsledku

10

Strana od-do

1579-1588

Kód UT WoS článku

000572342400001

EID výsledku v databázi Scopus

2-s2.0-85091386861