LVSP and LBBP Result in Similar or Improved LV Synchrony and Hemodynamics Compared to BVP

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F24%3A00588405" target="_blank" >RIV/68081731:_____/24:00588405 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023001:_____/24:00084989 RIV/00216208:11120/24:43927087 RIV/00064173:_____/24:43927087

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S2405500X24003487" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2405500X24003487</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jacep.2024.04.022" target="_blank" >10.1016/j.jacep.2024.04.022</a>

Jazyk výsledku

angličtina

Název v původním jazyce

LVSP and LBBP Result in Similar or Improved LV Synchrony and Hemodynamics Compared to BVP

Popis výsledku v původním jazyce

Background: The effect of left ventricular septal myocardial pacing (LVSP) and left bundle branch pacing (LBBP) on ventricular synchrony and left ventricular (LV) hemodynamic status is poorly understood. Objectives: The aim of this study was to investigate the impact of LVSP and LBBP vs biventricular pacing (BVP) on ventricular electrical synchrony and hemodynamic status in cardiac resynchronization therapy patients. Methods: In cardiac resynchronization therapy candidates with LV conduction disease, ventricular synchrony was assessed by measuring QRS duration (QRSd) and using ultra-high-frequency electrocardiography. LV electrical dyssynchrony was assessed as the difference between the first activation in leads V1 1 to V8 8 to the last from leads V4 4 to V8. 8 . LV hemodynamic status was estimated using invasive systolic blood pressure measurement during multiple transitions between LBBP, LVSP, and BVP. Results: A total of 35 patients with a mean LV ejection fraction of 29% and a mean QRSd of 168 f 24 ms were included. Thirteen had ischemic cardiomyopathy. QRSd during BVP, LVSP, and LBBP was the same, but LBBP provided shorter LV electrical dyssynchrony than BVP (-10 ms, 95% CI:-16 to-4 ms, P = 0.001), the difference between LVSP and BVP was not significant (-5 ms, 95% CI:-12 to 1 ms, P = 0.10). LBBP was associated with higher systolic blood pressure than BVP (4%, 95% CI: 2%-5%, P < 0.001), whereas LVSP was not (1%, 95% CI: 0%-2%, P = 0.10). Hemodynamic differences during LBBP and LVSP vs BVP were more pronounced in nonischemic than ischemic patients. Conclusions: Ultra-high-frequency electrocardiography allowed the documentation of differences in LV synchrony between LBBP, LVSP, and BVP, which were not observed by measuring QRSd. LVSP provided the same LV synchrony and hemodynamic status as BVP, while LBBP was better than BVP in both. (c) 2024 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Název v anglickém jazyce

LVSP and LBBP Result in Similar or Improved LV Synchrony and Hemodynamics Compared to BVP

Popis výsledku anglicky

Background: The effect of left ventricular septal myocardial pacing (LVSP) and left bundle branch pacing (LBBP) on ventricular synchrony and left ventricular (LV) hemodynamic status is poorly understood. Objectives: The aim of this study was to investigate the impact of LVSP and LBBP vs biventricular pacing (BVP) on ventricular electrical synchrony and hemodynamic status in cardiac resynchronization therapy patients. Methods: In cardiac resynchronization therapy candidates with LV conduction disease, ventricular synchrony was assessed by measuring QRS duration (QRSd) and using ultra-high-frequency electrocardiography. LV electrical dyssynchrony was assessed as the difference between the first activation in leads V1 1 to V8 8 to the last from leads V4 4 to V8. 8 . LV hemodynamic status was estimated using invasive systolic blood pressure measurement during multiple transitions between LBBP, LVSP, and BVP. Results: A total of 35 patients with a mean LV ejection fraction of 29% and a mean QRSd of 168 f 24 ms were included. Thirteen had ischemic cardiomyopathy. QRSd during BVP, LVSP, and LBBP was the same, but LBBP provided shorter LV electrical dyssynchrony than BVP (-10 ms, 95% CI:-16 to-4 ms, P = 0.001), the difference between LVSP and BVP was not significant (-5 ms, 95% CI:-12 to 1 ms, P = 0.10). LBBP was associated with higher systolic blood pressure than BVP (4%, 95% CI: 2%-5%, P < 0.001), whereas LVSP was not (1%, 95% CI: 0%-2%, P = 0.10). Hemodynamic differences during LBBP and LVSP vs BVP were more pronounced in nonischemic than ischemic patients. Conclusions: Ultra-high-frequency electrocardiography allowed the documentation of differences in LV synchrony between LBBP, LVSP, and BVP, which were not observed by measuring QRSd. LVSP provided the same LV synchrony and hemodynamic status as BVP, while LBBP was better than BVP in both. (c) 2024 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JACC-Clinical Electrophysiology

ISSN

2405-500X

e-ISSN

2405-5018

Svazek periodika

10

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

11

Strana od-do

1722-1732

Kód UT WoS článku

001282699400001

EID výsledku v databázi Scopus

2-s2.0-85195079398