The state of vigilance and not antiseizure medication dosage drive variability in interictal epilepsy biomarkers

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F25%3A00638567" target="_blank" >RIV/68081731:_____/25:00638567 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00159816:_____/25:00082392 RIV/00216224:14110/25:00141884 RIV/00216305:26220/26:0199134

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1388245725006777" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1388245725006777</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clinph.2025.2110825" target="_blank" >10.1016/j.clinph.2025.2110825</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The state of vigilance and not antiseizure medication dosage drive variability in interictal epilepsy biomarkers

Popis výsledku v původním jazyce

Objective: During presurgical intracranial electroencephalography (iEEG) investigation, anti-seizure medication (ASM) is typically tapered to record seizures. Interictal biomarkers are critical for epileptogenic zone (EZ) localization. This study examines how ASM tapering and other confounding factors influence the rates and localization accuracy of interictal iEEG biomarkers. Methods: iEEG data from 19 patients were analyzed during two 24 h sections separated by at least seven days during > 10-day iEEG monitoring. ASM dosage, vigilance state, time of day, seizure proximity, and duration of monitoring were evaluated for their impact on interictal biomarker rates, spatial distribution and localization of the EZ. Results: Biomarker rates, spatial distributions, and EZ localization did not significantly differ between the two 24hour sections. The state of vigilance emerged as the most significant contributor explaining 22.7 % of the variability. Seizure proximity, time of day and ASM dosage contributed minimally, each accounting for <= 3.7 % of the variability. Conclusions: The state of vigilance is the most significant determinant of interictal biomarker variability, and exceeds the impact of all other confounding factors regarding biomarker rates, distribution, and EZ localization. Significance: These findings highlight the importance of vigilance state over ASM tapering, supporting the potential use of interictal biomarkers for EZ localization, regardless of ASM adjustments.

Název v anglickém jazyce

The state of vigilance and not antiseizure medication dosage drive variability in interictal epilepsy biomarkers

Popis výsledku anglicky

Objective: During presurgical intracranial electroencephalography (iEEG) investigation, anti-seizure medication (ASM) is typically tapered to record seizures. Interictal biomarkers are critical for epileptogenic zone (EZ) localization. This study examines how ASM tapering and other confounding factors influence the rates and localization accuracy of interictal iEEG biomarkers. Methods: iEEG data from 19 patients were analyzed during two 24 h sections separated by at least seven days during > 10-day iEEG monitoring. ASM dosage, vigilance state, time of day, seizure proximity, and duration of monitoring were evaluated for their impact on interictal biomarker rates, spatial distribution and localization of the EZ. Results: Biomarker rates, spatial distributions, and EZ localization did not significantly differ between the two 24hour sections. The state of vigilance emerged as the most significant contributor explaining 22.7 % of the variability. Seizure proximity, time of day and ASM dosage contributed minimally, each accounting for <= 3.7 % of the variability. Conclusions: The state of vigilance is the most significant determinant of interictal biomarker variability, and exceeds the impact of all other confounding factors regarding biomarker rates, distribution, and EZ localization. Significance: These findings highlight the importance of vigilance state over ASM tapering, supporting the potential use of interictal biomarkers for EZ localization, regardless of ASM adjustments.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30210 - Clinical neurology

Projekt

<a href="/cs/project/LX22NPO5107" target="_blank" >LX22NPO5107: Národní ústav pro neurologický výzkum</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Neurophysiology

ISSN

1388-2457

e-ISSN

1872-8952

Svazek periodika

177

Číslo periodika v rámci svazku

September

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

10

Strana od-do

2110825

Kód UT WoS článku

001555554600002

EID výsledku v databázi Scopus

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