Measurement of Cerebral Blood Flow by ASL MRI in Rat Models of Psychopathology and Psychopharmacological Interventions

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F25%3A00639967" target="_blank" >RIV/68081731:_____/25:00639967 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/rwe/10.1007/978-3-031-73368-0_166" target="_blank" >https://link.springer.com/rwe/10.1007/978-3-031-73368-0_166</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-3-031-73368-0_166" target="_blank" >10.1007/978-3-031-73368-0_166</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Measurement of Cerebral Blood Flow by ASL MRI in Rat Models of Psychopathology and Psychopharmacological Interventions

Popis výsledku v původním jazyce

This chapter explores the use of arterial spin labeling (ASL) magnetic resonance imaging (MRI) to measure cerebral blood flow (CBF) in rat models of psychopathology and psychopharmacological interventions. It provides a comprehensive overview of ASL as a non-invasive technique that uses blood as an endogenous tracer, offering high-quality perfusion images without the need for contrast agents. The chapter emphasizes ASL’s utility in assessing microvascular CBF changes in various experimental conditions, including pharmacological manipulations and rodent models of psychiatric disorders. It discusses critical aspects of experimental design, including the choice of animal models, strain selection, and control of variables such as stress and circadian rhythms. The chapter also highlights the translational potential of ASL in neuropsychiatric research, particularly in understanding disease mechanisms and evaluating treatment effects. Ultimately, ASL MRI is presented as a valuable tool for preclinical research with significant implications for clinical applications.

Název v anglickém jazyce

Measurement of Cerebral Blood Flow by ASL MRI in Rat Models of Psychopathology and Psychopharmacological Interventions

Popis výsledku anglicky

This chapter explores the use of arterial spin labeling (ASL) magnetic resonance imaging (MRI) to measure cerebral blood flow (CBF) in rat models of psychopathology and psychopharmacological interventions. It provides a comprehensive overview of ASL as a non-invasive technique that uses blood as an endogenous tracer, offering high-quality perfusion images without the need for contrast agents. The chapter emphasizes ASL’s utility in assessing microvascular CBF changes in various experimental conditions, including pharmacological manipulations and rodent models of psychiatric disorders. It discusses critical aspects of experimental design, including the choice of animal models, strain selection, and control of variables such as stress and circadian rhythms. The chapter also highlights the translational potential of ASL in neuropsychiatric research, particularly in understanding disease mechanisms and evaluating treatment effects. Ultimately, ASL MRI is presented as a valuable tool for preclinical research with significant implications for clinical applications.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Handbook of the Biology and Pathology of Mental Disorders

ISBN

978-3-031-73367-3

Počet stran výsledku

23

Strana od-do

3353-3375

Počet stran knihy

3457

Název nakladatele

Springer

Místo vydání

Cham

Kód UT WoS kapitoly

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