Translational Value of Proton MRS in Depression: Applications to Preclinical Models

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F25%3A00647862" target="_blank" >RIV/68081731:_____/25:00647862 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/rwe/10.1007/978-3-031-73368-0_39" target="_blank" >https://link.springer.com/rwe/10.1007/978-3-031-73368-0_39</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-3-031-73368-0_39" target="_blank" >10.1007/978-3-031-73368-0_39</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Translational Value of Proton MRS in Depression: Applications to Preclinical Models

Popis výsledku v původním jazyce

Major depressive disorder (MDD) is a chronic mental disease affecting over 300 million people worldwide with limited treatment options. Understanding the neurochemical processes in MDD is essential for developing innovative medications, and magnetic resonance spectroscopy ([[sup]]1[[/sup]]H MRS) is especially well-suited for its in vivo exploration. This chapter compares the consistent [[sup]]1[[/sup]]H MRS evidence from the animal models to the clinical findings. The clinical results largely correspond to the animal studies in the prefrontal cortex, where the higher choline and lower Glx (glutamate + glutamine) levels are reported. These markers indicate cell membrane turnover and neuronal metabolism dysfunction. The hippocampus in MDD patients is understudied in the clinical field making an assessment of consistency of preclinical and clinical findings impossible. The use of [[sup]]1[[/sup]]H MRS method provides new insights into neuro-molecular process in MDD and has a potential to become a useful biomarker for tracking the success of treatment interventions in MDD.

Název v anglickém jazyce

Translational Value of Proton MRS in Depression: Applications to Preclinical Models

Popis výsledku anglicky

Major depressive disorder (MDD) is a chronic mental disease affecting over 300 million people worldwide with limited treatment options. Understanding the neurochemical processes in MDD is essential for developing innovative medications, and magnetic resonance spectroscopy ([[sup]]1[[/sup]]H MRS) is especially well-suited for its in vivo exploration. This chapter compares the consistent [[sup]]1[[/sup]]H MRS evidence from the animal models to the clinical findings. The clinical results largely correspond to the animal studies in the prefrontal cortex, where the higher choline and lower Glx (glutamate + glutamine) levels are reported. These markers indicate cell membrane turnover and neuronal metabolism dysfunction. The hippocampus in MDD patients is understudied in the clinical field making an assessment of consistency of preclinical and clinical findings impossible. The use of [[sup]]1[[/sup]]H MRS method provides new insights into neuro-molecular process in MDD and has a potential to become a useful biomarker for tracking the success of treatment interventions in MDD.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Handbook of the Biology and Pathology of Mental Disorders

ISBN

978-3-031-73367-3

Počet stran výsledku

22

Strana od-do

941-962

Počet stran knihy

3457

Název nakladatele

Springer

Místo vydání

Cham

Kód UT WoS kapitoly

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