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Early and late infarct growth rate in ischemic stroke patients after successful endovascular treatment in early time window: correlation of imaging and clinical factors with clinical outcome

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081740%3A_____%2F23%3A00574833" target="_blank" >RIV/68081740:_____/23:00574833 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00216208:11130/23:10466652 RIV/00216208:11120/23:43925921 RIV/00064173:_____/23:43925921

  • Výsledek na webu

    <a href="https://qims.amegroups.org/article/view/116200/pdf" target="_blank" >https://qims.amegroups.org/article/view/116200/pdf</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.21037/qims-23-153" target="_blank" >10.21037/qims-23-153</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Early and late infarct growth rate in ischemic stroke patients after successful endovascular treatment in early time window: correlation of imaging and clinical factors with clinical outcome

  • Popis výsledku v původním jazyce

    Background: The prospective study assessed infarct growth rate (IGR) in acute ischemic stroke (AIS) with large vessel occlusion (LVO) after recanalization in early time window. Early IGR (EIGR) and late IGR (LIGR) were correlated with imaging and clinical data, we searched for outcome predictors.Methods: We included 71 consecutive patients. Subjects underwent computed tomography perfusion (CTP) for ischemic core volume assessment at 99.0 minutes (median) from stroke onset, recanalization was performed at 78.0 minutes (median) from CTP. Final infarct volume (FIV) was measured on 24 & PLUSMN, 2 hours imaging follow-up. EIGR was calculated as the core volume/time between stroke onset and CTP, LIGR was calculated as FIV/time between CTP and imaging follow-up. Twenty-two subjects were assessed as poor outcome, 49 as good outcome. Group differences were tested by Mann-Whitney test and & chi,2 test. Bayesian logistic regression models were used to predict clinical outcome, Pearson correlations for the log transformed predictors.Results: Subjects with poor outcome were older, median age 78.0 [interquartile range (IQR): 71.8, 83.8] versus 68.0 (IQR: 57.0, 73.0) years, 95% confidence interval (CI): 6.00 to 16.00, P<0.001. Their stroke severity scale was higher, median 19.0 (IQR: 16.0, 20.0) versus 15.5 (IQR: 10.8, 18.0), 95% CI: 1.00 to 6.00, P<0.001. They had higher EIGR, median 23.9 (IQR: 6.4, 104.0) versus 6.7 (IQR: 1.7, 13.0) mL/h, 95% CI: 3.26 to 53.68, P=0.002, and larger core, median 52.5 (IQR: 13.1, 148.5) versus 10.0 (IQR: 1.4, 20.0) mL, 95% CI: 11.00 to 81.00, P<0.001. In subjects with poor outcome, infarct growth continued after thrombectomy with LIGR 2.0 (IQR: 1.2, 9.7) versus 0.3 (IQR: 0.0, 0.7) mL/h, 95% CI: 1.10 to 6.10, P<0.001, resulting in larger FIV, median 186.5 (IQR: 49.3, 280.8) versus 18.5 (IQR: 8.0, 34.0) mL, 95% CI: 55.30 to 214.00, P<0.001. Strong correlations among predictors were found e.g., core and EIGR (r=0.942), LIGR and FIV (r=0.779), core and FIV (r=0.761). Clinical outcome was best predicted using data from later measurements as FIV and LIGR.Conclusions: Data from later measurements were more predictive, there was no major benefit to use growth over volume data.

  • Název v anglickém jazyce

    Early and late infarct growth rate in ischemic stroke patients after successful endovascular treatment in early time window: correlation of imaging and clinical factors with clinical outcome

  • Popis výsledku anglicky

    Background: The prospective study assessed infarct growth rate (IGR) in acute ischemic stroke (AIS) with large vessel occlusion (LVO) after recanalization in early time window. Early IGR (EIGR) and late IGR (LIGR) were correlated with imaging and clinical data, we searched for outcome predictors.Methods: We included 71 consecutive patients. Subjects underwent computed tomography perfusion (CTP) for ischemic core volume assessment at 99.0 minutes (median) from stroke onset, recanalization was performed at 78.0 minutes (median) from CTP. Final infarct volume (FIV) was measured on 24 & PLUSMN, 2 hours imaging follow-up. EIGR was calculated as the core volume/time between stroke onset and CTP, LIGR was calculated as FIV/time between CTP and imaging follow-up. Twenty-two subjects were assessed as poor outcome, 49 as good outcome. Group differences were tested by Mann-Whitney test and & chi,2 test. Bayesian logistic regression models were used to predict clinical outcome, Pearson correlations for the log transformed predictors.Results: Subjects with poor outcome were older, median age 78.0 [interquartile range (IQR): 71.8, 83.8] versus 68.0 (IQR: 57.0, 73.0) years, 95% confidence interval (CI): 6.00 to 16.00, P<0.001. Their stroke severity scale was higher, median 19.0 (IQR: 16.0, 20.0) versus 15.5 (IQR: 10.8, 18.0), 95% CI: 1.00 to 6.00, P<0.001. They had higher EIGR, median 23.9 (IQR: 6.4, 104.0) versus 6.7 (IQR: 1.7, 13.0) mL/h, 95% CI: 3.26 to 53.68, P=0.002, and larger core, median 52.5 (IQR: 13.1, 148.5) versus 10.0 (IQR: 1.4, 20.0) mL, 95% CI: 11.00 to 81.00, P<0.001. In subjects with poor outcome, infarct growth continued after thrombectomy with LIGR 2.0 (IQR: 1.2, 9.7) versus 0.3 (IQR: 0.0, 0.7) mL/h, 95% CI: 1.10 to 6.10, P<0.001, resulting in larger FIV, median 186.5 (IQR: 49.3, 280.8) versus 18.5 (IQR: 8.0, 34.0) mL, 95% CI: 55.30 to 214.00, P<0.001. Strong correlations among predictors were found e.g., core and EIGR (r=0.942), LIGR and FIV (r=0.779), core and FIV (r=0.761). Clinical outcome was best predicted using data from later measurements as FIV and LIGR.Conclusions: Data from later measurements were more predictive, there was no major benefit to use growth over volume data.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    50101 - Psychology (including human - machine relations)

Návaznosti výsledku

  • Projekt

  • Návaznosti

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Ostatní

  • Rok uplatnění

    2023

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Quantitative Imaging and Surgery

  • ISSN

    2223-4292

  • e-ISSN

    2223-4306

  • Svazek periodika

    13

  • Číslo periodika v rámci svazku

    9

  • Stát vydavatele periodika

    CN - Čínská lidová republika

  • Počet stran výsledku

    13

  • Strana od-do

    5770-5782

  • Kód UT WoS článku

    001046323400001

  • EID výsledku v databázi Scopus

    2-s2.0-85171194021