Polymorfismus sterility hybridnich samcu v proximální oblasti chromosomu 17 v liniich odvozenych z divokych populaci Mus musculus musculus

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F09%3A00316413" target="_blank" >RIV/68081766:_____/09:00316413 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68081766:_____/09:00341631 RIV/62157124:16370/09:00002100

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Polymorphism in hybrid male sterility in wild-derived Mus musculus musculus strains on proximal chromosome 17

Popis výsledku v původním jazyce

The hybrid sterility-1 (Hst1) locus at Chr 17 causes male sterility in crosses between the house mouse subspecies. We derived two strains, STUS and STUF, that produce sterile and fertile males, respectively, in crosses withC57BL mice. To determine the genetic basis underlying male fertility, the (STUSxSTUF)F1females were mated to C57BL/10J males. Sterile males had a significantly smaller epididymis and testes than parental animals, and lacked spermatozoa due to meiotic arrest. The remaining fertile males displayed no deviation from values found in parental individuals. QTL analysis of the progeny revealed strong associations of male?s fitness components with the proximal end of Chr 17, and a significant effect of the central section of Chr X on testesmass. The data suggest that genetic incompatibilities associated with male sterility have evolved independently at the proximal end of Chr 17 and are polymorphic within both M. m. domesticus and M. m. musculus genomes.

Název v anglickém jazyce

Polymorphism in hybrid male sterility in wild-derived Mus musculus musculus strains on proximal chromosome 17

Popis výsledku anglicky

The hybrid sterility-1 (Hst1) locus at Chr 17 causes male sterility in crosses between the house mouse subspecies. We derived two strains, STUS and STUF, that produce sterile and fertile males, respectively, in crosses withC57BL mice. To determine the genetic basis underlying male fertility, the (STUSxSTUF)F1females were mated to C57BL/10J males. Sterile males had a significantly smaller epididymis and testes than parental animals, and lacked spermatozoa due to meiotic arrest. The remaining fertile males displayed no deviation from values found in parental individuals. QTL analysis of the progeny revealed strong associations of male?s fitness components with the proximal end of Chr 17, and a significant effect of the central section of Chr X on testesmass. The data suggest that genetic incompatibilities associated with male sterility have evolved independently at the proximal end of Chr 17 and are polymorphic within both M. m. domesticus and M. m. musculus genomes.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mammalian Genome

ISSN

0938-8990

e-ISSN

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Svazek periodika

20

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

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Kód UT WoS článku

000263147900003

EID výsledku v databázi Scopus

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