The effects of ciprofloxacin on early life stages of common carp (Cyprinus carpio)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F16%3A00453699" target="_blank" >RIV/68081766:_____/16:00453699 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16170/16:43874360 RIV/62157124:16270/16:43874360

Výsledek na webu

<a href="http://dx.doi.org/10.1002/etc.3317" target="_blank" >http://dx.doi.org/10.1002/etc.3317</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/etc.3317" target="_blank" >10.1002/etc.3317</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The effects of ciprofloxacin on early life stages of common carp (Cyprinus carpio)

Popis výsledku v původním jazyce

We performed our toxicity test with ciprofloxacin (CIP) according to OECD 210, in which we used fertilized eggs of common carp. The tested concentrations were 1, 100, 500, 1000, and 3000 µg L1. We found accelerated hatching in all groups exposed to CIP, but significant growth reduction only in the group exposed to the highest concentration of CIP (3000 µg L1). An increased number of macroscopic morphological anomalies were observed on day 6 of the test (after hatching). The highest numbers of macroscopic morphological anomalies were observed in the groups of free embryos and larvae exposed to CIP concentrations of 100, 500, 1000 and 3000 µg L1 (20  23% of tested samples). A gradual decrease of glutathione S-transferase activity was detected in all experimental groups exposed to CIP, but significant differences (p < 0.01) were found only in groups treated with 500 and 3000 µg L1. Glutathione peroxidase and catalase exhibited increased activity in majority of the tested concentrations (p < 0.01, p < 0.05), while decreased glutathione reductase activity was found in the groups exposed to CIP concentrations of 500 and 3000 µg L1 (p < 0.05). The concentration of thiobarbituric acid reactive substances was significantly lower (p < 0.01) in all experimental groups exposed to CIP. The lowest observed effect concentration (LOEC) of CIP was 1 µg L1. These results suggest that hatching, early ontogeny, occurrence of morphological anomalies, activity of antioxidant and biotransformation enzymes and lipid peroxidation in fish can be affected by CIP.

Název v anglickém jazyce

The effects of ciprofloxacin on early life stages of common carp (Cyprinus carpio)

Popis výsledku anglicky

We performed our toxicity test with ciprofloxacin (CIP) according to OECD 210, in which we used fertilized eggs of common carp. The tested concentrations were 1, 100, 500, 1000, and 3000 µg L1. We found accelerated hatching in all groups exposed to CIP, but significant growth reduction only in the group exposed to the highest concentration of CIP (3000 µg L1). An increased number of macroscopic morphological anomalies were observed on day 6 of the test (after hatching). The highest numbers of macroscopic morphological anomalies were observed in the groups of free embryos and larvae exposed to CIP concentrations of 100, 500, 1000 and 3000 µg L1 (20  23% of tested samples). A gradual decrease of glutathione S-transferase activity was detected in all experimental groups exposed to CIP, but significant differences (p < 0.01) were found only in groups treated with 500 and 3000 µg L1. Glutathione peroxidase and catalase exhibited increased activity in majority of the tested concentrations (p < 0.01, p < 0.05), while decreased glutathione reductase activity was found in the groups exposed to CIP concentrations of 500 and 3000 µg L1 (p < 0.05). The concentration of thiobarbituric acid reactive substances was significantly lower (p < 0.01) in all experimental groups exposed to CIP. The lowest observed effect concentration (LOEC) of CIP was 1 µg L1. These results suggest that hatching, early ontogeny, occurrence of morphological anomalies, activity of antioxidant and biotransformation enzymes and lipid peroxidation in fish can be affected by CIP.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EG - Zoologie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Environmental Toxicology and Chemistry

ISSN

0730-7268

e-ISSN

—

Svazek periodika

35

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

1733-1740

Kód UT WoS článku

000379547900015

EID výsledku v databázi Scopus

2-s2.0-84976588017