Relaxed selection limits lifespan by increasing mutation load

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F19%3A00506728" target="_blank" >RIV/68081766:_____/19:00506728 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.cell.2019.06.004" target="_blank" >http://dx.doi.org/10.1016/j.cell.2019.06.004</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cell.2019.06.004" target="_blank" >10.1016/j.cell.2019.06.004</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Relaxed selection limits lifespan by increasing mutation load

Popis výsledku v původním jazyce

To uncover the selective forces shaping life-history trait evolution across species, we investigate the genomic basis underlying adaptations to seasonal habitat desiccation in African killifishes, identifying the genetic variants associated with positive and relaxed purifying selection in 45 killifish species and 231 wild individuals distributed throughout sub-Saharan Africa. In annual species, genetic drift led to the expansion of nuclear and mitochondrial genomes and caused the accumulation of deleterious genetic variants in key life-history modulating genes such as mtor, insr, ampk, foxo3, and polg. Relaxation of purifying selection is also significantly associated with mitochondrial function and aging in human populations. We find that relaxation of purifying selection prominently shapes genomes and is a prime candidate force molding the evolution of lifespan and the distribution of genetic variants associated with late-onset diseases in different species. Video Abstract. Studying the genomic changes accompanying the repeated evolution of short lifespan in 45 African killifish species reveals that neutral genetic drift, rather than adaptive evolution, explains the accumulation of deleterious gene variants affecting lifespan and aging.

Název v anglickém jazyce

Relaxed selection limits lifespan by increasing mutation load

Popis výsledku anglicky

To uncover the selective forces shaping life-history trait evolution across species, we investigate the genomic basis underlying adaptations to seasonal habitat desiccation in African killifishes, identifying the genetic variants associated with positive and relaxed purifying selection in 45 killifish species and 231 wild individuals distributed throughout sub-Saharan Africa. In annual species, genetic drift led to the expansion of nuclear and mitochondrial genomes and caused the accumulation of deleterious genetic variants in key life-history modulating genes such as mtor, insr, ampk, foxo3, and polg. Relaxation of purifying selection is also significantly associated with mitochondrial function and aging in human populations. We find that relaxation of purifying selection prominently shapes genomes and is a prime candidate force molding the evolution of lifespan and the distribution of genetic variants associated with late-onset diseases in different species. Video Abstract. Studying the genomic changes accompanying the repeated evolution of short lifespan in 45 African killifish species reveals that neutral genetic drift, rather than adaptive evolution, explains the accumulation of deleterious gene variants affecting lifespan and aging.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

Projekt

<a href="/cs/project/GA19-01781S" target="_blank" >GA19-01781S: Zdroje vnitropopulační heterogenity ve stárnutí</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cell

ISSN

0092-8674

e-ISSN

—

Svazek periodika

178

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

35

Strana od-do

"385"-"399.e20"

Kód UT WoS článku

000475357200013

EID výsledku v databázi Scopus

2-s2.0-85068416932