Genotype and haplotype analysis of cell cycle genes in sporadic colorectal cancer in Czech Republic

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F09%3A00314441" target="_blank" >RIV/68378041:_____/09:00314441 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Genotype and haplotype analysis of cell cycle genes in sporadic colorectal cancer in Czech Republic

Popis výsledku v původním jazyce

To assess the role of genetic variants on the disease, we genotyped polymorphisms in the TP53 (rs17878362:A1>A2, rs1042522:G>C, rs12947788:C>T, and rs17884306:G>A), CDKN1A (rs1801270:C>A and rs1059234:C>T), and CDKN2A (rs3731249:G>A, rs11515:C>G, and rs3088440:C>T) genes in 614 hospital-based colorectal cancer cases and 614 matched controls from the country. The two most common haplotypes, A1GCG and A2CCG were present in 81% of the cases compared to 71% of the controls. In comparison to the most commonhaplotype (A1GCG), the haplotype A2CCG was associated with an increased risk (odds ratio OR 1.40, 95% confidence interval CI 1.07-1.82), while the four other haplotypes A1CCG (OR 0.60 95% CI 0.45-0.79), A2GCG (OR 0.53 95% CI 0.35-0.81), A1GTG (OR 0.31 95% CI 0.15-0.64), and A1GCA (OR 0.19 95% CI 0.07-0.51) were associated with a decreased risk. No association with the disease was observed with haplotypes of the CDKN1A and CDKN2A polymorphisms.

Název v anglickém jazyce

Genotype and haplotype analysis of cell cycle genes in sporadic colorectal cancer in Czech Republic

Popis výsledku anglicky

To assess the role of genetic variants on the disease, we genotyped polymorphisms in the TP53 (rs17878362:A1>A2, rs1042522:G>C, rs12947788:C>T, and rs17884306:G>A), CDKN1A (rs1801270:C>A and rs1059234:C>T), and CDKN2A (rs3731249:G>A, rs11515:C>G, and rs3088440:C>T) genes in 614 hospital-based colorectal cancer cases and 614 matched controls from the country. The two most common haplotypes, A1GCG and A2CCG were present in 81% of the cases compared to 71% of the controls. In comparison to the most commonhaplotype (A1GCG), the haplotype A2CCG was associated with an increased risk (odds ratio OR 1.40, 95% confidence interval CI 1.07-1.82), while the four other haplotypes A1CCG (OR 0.60 95% CI 0.45-0.79), A2GCG (OR 0.53 95% CI 0.35-0.81), A1GTG (OR 0.31 95% CI 0.15-0.64), and A1GCA (OR 0.19 95% CI 0.07-0.51) were associated with a decreased risk. No association with the disease was observed with haplotypes of the CDKN1A and CDKN2A polymorphisms.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

—

Projekt

<a href="/cs/project/GA310%2F07%2F1430" target="_blank" >GA310/07/1430: Molekulární a genetické charakteristiky sporadických nádorů tlustého střeva a konečníku sledované v české populaci.</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Human Mutation

ISSN

1059-7794

e-ISSN

—

Svazek periodika

30

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

—

Kód UT WoS článku

000265006400021

EID výsledku v databázi Scopus

—