Hemoglobin adducts in 1,3-butadiene exposed Czech workers: Female?male comparisons

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Hemoglobin adducts in 1,3-butadiene exposed Czech workers: Female?male comparisons

Popis výsledku v původním jazyce

The results of this study confirm the findings of the previous molecular epidemiological study of female and male 1,3-butadiene (BD) exposed Czech workers, showing that females appeared to absorb or metabolize less BD per unit exposure conc. that did males (based on metabolite conc. in urine). In this study, another biomarker to measure a second metabolite of BD was used. The authors measured production and accumulation of the 1,2-dihydroxy-3,4-epoxybutane (EBD) metabolite as reflected in THB-Val hemoglobin adduct concentrations. In both the control and exposed groups mean THB-Val concentrations were significantly higher for males than females. It was also found that the size of difference increased with exposure.

Název v anglickém jazyce

Hemoglobin adducts in 1,3-butadiene exposed Czech workers: Female?male comparisons

Popis výsledku anglicky

The results of this study confirm the findings of the previous molecular epidemiological study of female and male 1,3-butadiene (BD) exposed Czech workers, showing that females appeared to absorb or metabolize less BD per unit exposure conc. that did males (based on metabolite conc. in urine). In this study, another biomarker to measure a second metabolite of BD was used. The authors measured production and accumulation of the 1,2-dihydroxy-3,4-epoxybutane (EBD) metabolite as reflected in THB-Val hemoglobin adduct concentrations. In both the control and exposed groups mean THB-Val concentrations were significantly higher for males than females. It was also found that the size of difference increased with exposure.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

DN - Vliv životního prostředí na zdraví

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemico-Biological Interactions

ISSN

0009-2797

e-ISSN

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Svazek periodika

188

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

9

Strana od-do

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Kód UT WoS článku

000285169100035

EID výsledku v databázi Scopus

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