Sex-Specific Formation of 1,2:3,4-Diepoxybutane-Derived Hemoglobin Adducts in 1,3-Butadiene-Exposed Workers

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F25%3A00635580" target="_blank" >RIV/68378041:_____/25:00635580 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubs.acs.org/doi/10.1021/acs.chemrestox.4c00530" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.chemrestox.4c00530</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.chemrestox.4c00530" target="_blank" >10.1021/acs.chemrestox.4c00530</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Sex-Specific Formation of 1,2:3,4-Diepoxybutane-Derived Hemoglobin Adducts in 1,3-Butadiene-Exposed Workers

Popis výsledku v původním jazyce

1,3-Butadiene (BD) is an important industrial chemical that is classified as a human carcinogen. BD carcinogenicity has been attributed to several reactive epoxide metabolites, and the formation of highly mutagenic 1,2:3,4-diepoxybutane (DEB) has been suggested to drive mutagenesis and carcinogenesis at exposures experienced in humans. We report herein the formation of DEB-specific N,N-(2,3-dihydroxy-1,4-butadiyl)-valine (pyr-Val) in occupationally BD-exposed workers as an indirect biomarker of DEB-induced mutagenicity. pyr-Val was determined in BD-monomer and -polymer plant workers that had been previously analyzed for several other biomarkers of exposure and effect. In this second study, pyr-Val was detected in 92 out of 94 (98%) individuals, ranging from 0.001 to 0.697 pmol/g of globin. Surprisingly, pyr-Val was observed in 43 of 44 administrative control subjects not known to be exposed to BD, suggesting environmental sources of BD. The mean ± SD amounts of pyr-Val were 0.049 ± 0.044, 0.029 ± 0.032, 0.030 ± 0.035, and 0.074 ± 0.093 pmol/g globin in female control, female exposed, male control, and male exposed, respectively, clearly demonstrating the formation of DEB in environmentally and occupationally exposed BD workers. The amounts of pyr-Val found in this study suggest that humans are much less efficient in the formation of DEB than mice or rats at similar BD exposures. The formation of pyr-Val was lower than that associated with increased mutagenesis in rodents.

Název v anglickém jazyce

Sex-Specific Formation of 1,2:3,4-Diepoxybutane-Derived Hemoglobin Adducts in 1,3-Butadiene-Exposed Workers

Popis výsledku anglicky

1,3-Butadiene (BD) is an important industrial chemical that is classified as a human carcinogen. BD carcinogenicity has been attributed to several reactive epoxide metabolites, and the formation of highly mutagenic 1,2:3,4-diepoxybutane (DEB) has been suggested to drive mutagenesis and carcinogenesis at exposures experienced in humans. We report herein the formation of DEB-specific N,N-(2,3-dihydroxy-1,4-butadiyl)-valine (pyr-Val) in occupationally BD-exposed workers as an indirect biomarker of DEB-induced mutagenicity. pyr-Val was determined in BD-monomer and -polymer plant workers that had been previously analyzed for several other biomarkers of exposure and effect. In this second study, pyr-Val was detected in 92 out of 94 (98%) individuals, ranging from 0.001 to 0.697 pmol/g of globin. Surprisingly, pyr-Val was observed in 43 of 44 administrative control subjects not known to be exposed to BD, suggesting environmental sources of BD. The mean ± SD amounts of pyr-Val were 0.049 ± 0.044, 0.029 ± 0.032, 0.030 ± 0.035, and 0.074 ± 0.093 pmol/g globin in female control, female exposed, male control, and male exposed, respectively, clearly demonstrating the formation of DEB in environmentally and occupationally exposed BD workers. The amounts of pyr-Val found in this study suggest that humans are much less efficient in the formation of DEB than mice or rats at similar BD exposures. The formation of pyr-Val was lower than that associated with increased mutagenesis in rodents.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10511 - Environmental sciences (social aspects to be 5.7)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemical Research in Toxicology

ISSN

0893-228X

e-ISSN

1520-5010

Svazek periodika

38

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

858-864

Kód UT WoS článku

001472493300001

EID výsledku v databázi Scopus

2-s2.0-105003776857