1,3-Butadiene: Biomarkers and application to risk assessment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F11%3A00350229" target="_blank" >RIV/68378041:_____/11:00350229 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.cbi.2010.10.010" target="_blank" >http://dx.doi.org/10.1016/j.cbi.2010.10.010</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cbi.2010.10.010" target="_blank" >10.1016/j.cbi.2010.10.010</a>

Jazyk výsledku

angličtina

Název v původním jazyce

1,3-Butadiene: Biomarkers and application to risk assessment

Popis výsledku v původním jazyce

1,3-Butadiene (BD) is a known human carcinogen that is metabolized mainly by P450 2E1 to three epoxides (EB, DEB and EB-diol). These epoxides vary in their mutagenic potency, with DEB being the most mutagenic metabolite. It is important to understand theinternal formation of the individual epoxides to assign the relative risk for each metabolite and to understand the molecular mechanisms responsible for differences in carcinogenicity. In the extensive exposure-biomarker studies on mice, rats and humanswas found that using low exposures that range from current occupational levels to human exposures from tobacco smoke mice are very different from humans, with mice forming 200 times more DEB than humans at exposures of 0.1-1.5ppm BD. These data providea scientific basis for improved risk assessment of BD.

Název v anglickém jazyce

1,3-Butadiene: Biomarkers and application to risk assessment

Popis výsledku anglicky

1,3-Butadiene (BD) is a known human carcinogen that is metabolized mainly by P450 2E1 to three epoxides (EB, DEB and EB-diol). These epoxides vary in their mutagenic potency, with DEB being the most mutagenic metabolite. It is important to understand theinternal formation of the individual epoxides to assign the relative risk for each metabolite and to understand the molecular mechanisms responsible for differences in carcinogenicity. In the extensive exposure-biomarker studies on mice, rats and humanswas found that using low exposures that range from current occupational levels to human exposures from tobacco smoke mice are very different from humans, with mice forming 200 times more DEB than humans at exposures of 0.1-1.5ppm BD. These data providea scientific basis for improved risk assessment of BD.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

DN - Vliv životního prostředí na zdraví

OECD FORD obor

—

Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemico-Biological Interactions

ISSN

0009-2797

e-ISSN

—

Svazek periodika

192

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

5

Strana od-do

150-154

Kód UT WoS článku

000292435100026

EID výsledku v databázi Scopus

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