The effect of parvalbumin deficiency on the acoustic startle response and prepulse inhibition in mice

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F13%3A00396572" target="_blank" >RIV/68378041:_____/13:00396572 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.neulet.2013.08.042" target="_blank" >http://dx.doi.org/10.1016/j.neulet.2013.08.042</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.neulet.2013.08.042" target="_blank" >10.1016/j.neulet.2013.08.042</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The effect of parvalbumin deficiency on the acoustic startle response and prepulse inhibition in mice

Popis výsledku v původním jazyce

The strength of the acoustic startle response (ASR) to short bursts of broadband noise or tone pips (4, 8 and 16 kHz) and the prepulse inhibition (PPI) of the ASR elicited by prepulse tones (4, 8 and 16 kHz) were measured in parvalbumin-deficient (PV-/-)mice and in age-matched PV+/+ mice as controls. In PV-/- mice, we observed smaller ASR amplitudes in response to relatively weak startling stimuli (80-90 dB SPL) of either broadband noise or 8-kHz tones compared to those recorded in PV+/+ mice. For these startling stimuli, PV-/- mice had higher ASR thresholds and longer ASR latencies. PPI of the ASR in PV-/- mice was less effective than in PV+/+ mice, for all tested prepulse frequencies (4, 8 or 16 kHz) at 70 dB SPL. Our findings demonstrate no effectof PV deficiency on hearing threshold as determined from recordings of auditory brainstem responses in PV -/- mice. However, the frequency-specific differences in the ASR and the significant reduction of PPI of ASR reflect specific change

Název v anglickém jazyce

The effect of parvalbumin deficiency on the acoustic startle response and prepulse inhibition in mice

Popis výsledku anglicky

The strength of the acoustic startle response (ASR) to short bursts of broadband noise or tone pips (4, 8 and 16 kHz) and the prepulse inhibition (PPI) of the ASR elicited by prepulse tones (4, 8 and 16 kHz) were measured in parvalbumin-deficient (PV-/-)mice and in age-matched PV+/+ mice as controls. In PV-/- mice, we observed smaller ASR amplitudes in response to relatively weak startling stimuli (80-90 dB SPL) of either broadband noise or 8-kHz tones compared to those recorded in PV+/+ mice. For these startling stimuli, PV-/- mice had higher ASR thresholds and longer ASR latencies. PPI of the ASR in PV-/- mice was less effective than in PV+/+ mice, for all tested prepulse frequencies (4, 8 or 16 kHz) at 70 dB SPL. Our findings demonstrate no effectof PV deficiency on hearing threshold as determined from recordings of auditory brainstem responses in PV -/- mice. However, the frequency-specific differences in the ASR and the significant reduction of PPI of ASR reflect specific change

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuroscience Letters

ISSN

0304-3940

e-ISSN

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Svazek periodika

553

Číslo periodika v rámci svazku

October

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

5

Strana od-do

216-220

Kód UT WoS článku

000326008700041

EID výsledku v databázi Scopus

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