Macrophages and Toxicity of Nanomaterials: a mini-review

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F16%3A00476180" target="_blank" >RIV/68378041:_____/16:00476180 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Macrophages and Toxicity of Nanomaterials: a mini-review

Popis výsledku v původním jazyce

Nanomaterials (NM) and nanotechnologies have a potential to revolutionize many aspects of human life, including medicine, personal care, energy production, and environmental protection. For a safe and sustainable use of any new technology, possible adverse health effects should be investigated alongside with the technology development. Unique NM properties that are desirable in novel applications may give rise to unexpected toxicities. From the perspective of the immune system, NM represent invading agents. Macrophages, as the first-line defense against foreign objects that entered the body, are tasked (i) to recognize if these objects (e.g. NM) might pose a theat to the organism, (ii)to trigger appropriate reactions. The recognition of NM by macrophages and subsequent NM-macrophages interactions can therefore determine the fate of the NM as well as their potential toxic effects. The present chapter focuses on ways by which NM disrupt or excessively activate macrophage functions and they will be discussed in the context of potential pathological consequences.

Název v anglickém jazyce

Macrophages and Toxicity of Nanomaterials: a mini-review

Popis výsledku anglicky

Nanomaterials (NM) and nanotechnologies have a potential to revolutionize many aspects of human life, including medicine, personal care, energy production, and environmental protection. For a safe and sustainable use of any new technology, possible adverse health effects should be investigated alongside with the technology development. Unique NM properties that are desirable in novel applications may give rise to unexpected toxicities. From the perspective of the immune system, NM represent invading agents. Macrophages, as the first-line defense against foreign objects that entered the body, are tasked (i) to recognize if these objects (e.g. NM) might pose a theat to the organism, (ii)to trigger appropriate reactions. The recognition of NM by macrophages and subsequent NM-macrophages interactions can therefore determine the fate of the NM as well as their potential toxic effects. The present chapter focuses on ways by which NM disrupt or excessively activate macrophage functions and they will be discussed in the context of potential pathological consequences.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

30304 - Public and environmental health

Projekt

<a href="/cs/project/LO1508" target="_blank" >LO1508: Genomika a proteomika při studiu mechanismů biologických účinků vyráběných nanočástic</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Novel Biomaterials in Regenerative Medicine

ISBN

978-80-88113-69-0

Počet stran výsledku

16

Strana od-do

230-245

Počet stran knihy

276

Název nakladatele

Epika

Místo vydání

2016

Kód UT WoS kapitoly

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