Oxidative stress in newborns by different modes of delivery

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F16%3A00480253" target="_blank" >RIV/68378041:_____/16:00480253 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12110/16:43899428

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Oxidative stress in newborns by different modes of delivery

Popis výsledku v původním jazyce

OBJECTIVES: The aim of our study is to investigate the impact of the type of delivery -vaginal vs. cesarean section on oxidative damage determined as the lipid peroxidation (15-F2t-isoprostane (15-F2t-IsoP) in the cord blood of newborns and venous blood from mothers in two localities with different levels of air pollution: Ceske Budejovice (CB), a locality with a clean air, and Karvina, a locality with high air pollution.nRESUTLS: In Karvina, the concentration of PM2.5 was higher than in CB in the summer 2013 (mean +/- SD: 20.41 +/- 6.28 vs. 9.45 +/- 3.62 mu g/m3, p< 0.001) and in the winter 2014 (mean +/- SD: 53.67 +/- 19.76 vs. 27.96 +/- 12.34 mu g/m3, p< 0.001). Similarly, the concentration of B[a] P was higher in Karvina than in CB in the summer 2013 (mean +/- SD: 1.16 +/- 0.91 vs. 0.16 +/- 0.26 ng/m3, p< 0.001) and in the winter 2014 (5.36 +/- 3.64 vs. 1.45 +/- 1.19 ng/m3, p< 0.001). Delivery procedures differed by the type of anesthesia, at the Cesarean section in CB was used general anesthesia in 73.8% vs. 20.8% in Karvina (p< 0.001), epidural anesthesia in CB in 26.2% vs. 77.1% in Karvina (p< 0.001), at vaginal delivery was local anesthesia used in CB in 58.9% vs. 14.1% in Karvina (p< 0.001). In CB was oxidative stress higher after vaginal delivery (101.7 +/- 31.0 pg 15-F2t-isoP/ml plasma) vs. Cesarean section (83.9 +/- 26.9 pg 15-F2t-isoP/ml plasma, p< 0.001), no difference between the type of delivery was observed in Karvina. nCONCLUSION: No difference between the types of delivery was observed in mothers in CB as well as in Karvina. Oxidative stress in newborns in Karvina was significantly affected by the concentrations of PM2.5 and B[a] P in the polluted air.

Název v anglickém jazyce

Oxidative stress in newborns by different modes of delivery

Popis výsledku anglicky

OBJECTIVES: The aim of our study is to investigate the impact of the type of delivery -vaginal vs. cesarean section on oxidative damage determined as the lipid peroxidation (15-F2t-isoprostane (15-F2t-IsoP) in the cord blood of newborns and venous blood from mothers in two localities with different levels of air pollution: Ceske Budejovice (CB), a locality with a clean air, and Karvina, a locality with high air pollution.nRESUTLS: In Karvina, the concentration of PM2.5 was higher than in CB in the summer 2013 (mean +/- SD: 20.41 +/- 6.28 vs. 9.45 +/- 3.62 mu g/m3, p< 0.001) and in the winter 2014 (mean +/- SD: 53.67 +/- 19.76 vs. 27.96 +/- 12.34 mu g/m3, p< 0.001). Similarly, the concentration of B[a] P was higher in Karvina than in CB in the summer 2013 (mean +/- SD: 1.16 +/- 0.91 vs. 0.16 +/- 0.26 ng/m3, p< 0.001) and in the winter 2014 (5.36 +/- 3.64 vs. 1.45 +/- 1.19 ng/m3, p< 0.001). Delivery procedures differed by the type of anesthesia, at the Cesarean section in CB was used general anesthesia in 73.8% vs. 20.8% in Karvina (p< 0.001), epidural anesthesia in CB in 26.2% vs. 77.1% in Karvina (p< 0.001), at vaginal delivery was local anesthesia used in CB in 58.9% vs. 14.1% in Karvina (p< 0.001). In CB was oxidative stress higher after vaginal delivery (101.7 +/- 31.0 pg 15-F2t-isoP/ml plasma) vs. Cesarean section (83.9 +/- 26.9 pg 15-F2t-isoP/ml plasma, p< 0.001), no difference between the type of delivery was observed in Karvina. nCONCLUSION: No difference between the types of delivery was observed in mothers in CB as well as in Karvina. Oxidative stress in newborns in Karvina was significantly affected by the concentrations of PM2.5 and B[a] P in the polluted air.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30304 - Public and environmental health

Projekt

<a href="/cs/project/GA13-13458S" target="_blank" >GA13-13458S: Dopady znečištění ovzduší na genom novorozenců</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

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Svazek periodika

37

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

SE - Švédské království

Počet stran výsledku

12

Strana od-do

445-451

Kód UT WoS článku

000398579900007

EID výsledku v databázi Scopus

2-s2.0-85018675893