The use of pulsed magnetic fields to increase the uptake of iron oxide nanoparticles by living cells

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F17%3A00487767" target="_blank" >RIV/68378041:_____/17:00487767 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378271:_____/17:00484345 RIV/00023001:_____/17:00076218

Výsledek na webu

<a href="http://dx.doi.org/10.1063/1.5007797" target="_blank" >http://dx.doi.org/10.1063/1.5007797</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1063/1.5007797" target="_blank" >10.1063/1.5007797</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The use of pulsed magnetic fields to increase the uptake of iron oxide nanoparticles by living cells

Popis výsledku v původním jazyce

Remote control of the interaction of magnetic nanoparticles with cells is fundamental to any potential downstream applications of magnetic nanoparticles such as gene and drug delivery vehicles and magnetic cell labeling. Thus, approaches based on the application of external magnetic fields to increase the efficiency of magnetic cell labeling are desirable. Here, we report a simple approach that enhances magnetic cell labeling using pulsed magnetic fields. The rate of uptake of superparamagnetic iron oxide nanoparticles (SPIONs) and transport across the cell membrane were enhanced upon application of a high intensity (7T) short pulse width (similar to 15 mu s) magnetic field. We present a quantitative analysis and mechanistic explanation of how a pulsed magnetic field influences the uptake of SPIONs by cells. Our findings offer insights into the mechanics of how pulsed magnetic fields can be effectively used to optimize magnetic cell labeling, which can provide a basis for better controlled biomedical applications of SPIONs. Published by AIP Publishing.

Název v anglickém jazyce

The use of pulsed magnetic fields to increase the uptake of iron oxide nanoparticles by living cells

Popis výsledku anglicky

Remote control of the interaction of magnetic nanoparticles with cells is fundamental to any potential downstream applications of magnetic nanoparticles such as gene and drug delivery vehicles and magnetic cell labeling. Thus, approaches based on the application of external magnetic fields to increase the efficiency of magnetic cell labeling are desirable. Here, we report a simple approach that enhances magnetic cell labeling using pulsed magnetic fields. The rate of uptake of superparamagnetic iron oxide nanoparticles (SPIONs) and transport across the cell membrane were enhanced upon application of a high intensity (7T) short pulse width (similar to 15 mu s) magnetic field. We present a quantitative analysis and mechanistic explanation of how a pulsed magnetic field influences the uptake of SPIONs by cells. Our findings offer insights into the mechanics of how pulsed magnetic fields can be effectively used to optimize magnetic cell labeling, which can provide a basis for better controlled biomedical applications of SPIONs. Published by AIP Publishing.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10610 - Biophysics

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Applied Physics Letters

ISSN

0003-6951

e-ISSN

—

Svazek periodika

111

Číslo periodika v rámci svazku

24

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

—

Kód UT WoS článku

000418098900051

EID výsledku v databázi Scopus

2-s2.0-85038445881