lncRNAs in non-malignant tissue have prognostic value in colorectal cancer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F18%3A00495541" target="_blank" >RIV/68378041:_____/18:00495541 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.3390/ijms19092672" target="_blank" >http://dx.doi.org/10.3390/ijms19092672</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms19092672" target="_blank" >10.3390/ijms19092672</a>

Jazyk výsledku

angličtina

Název v původním jazyce

lncRNAs in non-malignant tissue have prognostic value in colorectal cancer

Popis výsledku v původním jazyce

Although colorectal cancer-CRC is the third most frequent cause of cancer related death in Europe, biomarkers for therapy guidance and prognosis are insufficiently reliable. Long non-coding RNAs are over 200 nucleotides long, they are not translated into proteins but can influence biological processes, as oncogenes, tumour suppressors or regulators of cell proliferation and metastasis development. We aimed to evaluate the prognostic effect of selected lncRNAs in a retrospective study on CRC patients from the Czech Republic. We have measured the expression in paired non-malignant and tumour tissues of CRC patients of nine lncRNAs previously shown to be involved in cancer progression-ANRIL, CCAT1, GAS5, linc-ROR, MALAT1, MIR155HG, PCAT1, SPRY4-IT1 and TUG1. A comparison of expression in tumour and non-malignant mucosa tissues showed significant upregulation of CCAT1 and linc-ROR in tumor tissue and downregulation of ANRIL, MIR155HG and MALAT1. Linc-ROR was significantly associated with the presence of synchronous metastases. For individual tissue types, lower MIR155HG expression in tumor tissue was correlated with both shorter overall survival and shorter disease-free survival. In non malignant tissue expression ratios of CCAT1/ANRIL and CCAT1/MIR155HG were significantly associated with overall survival. Our results revealed that changes in expression of lncRNAs between tumor and non-malignant issues could be used as prognostic biomarkers in CRC patients. Moreover, the ratios of CCAT1 to ANRIL and MIR155HG in non-malignant issue could be used for prognosis assessment. It seems that cancer progression is associated with detrimental system-wide changes in patient tissue, which might govern patient survival even after elimination of tumour.

Název v anglickém jazyce

lncRNAs in non-malignant tissue have prognostic value in colorectal cancer

Popis výsledku anglicky

Although colorectal cancer-CRC is the third most frequent cause of cancer related death in Europe, biomarkers for therapy guidance and prognosis are insufficiently reliable. Long non-coding RNAs are over 200 nucleotides long, they are not translated into proteins but can influence biological processes, as oncogenes, tumour suppressors or regulators of cell proliferation and metastasis development. We aimed to evaluate the prognostic effect of selected lncRNAs in a retrospective study on CRC patients from the Czech Republic. We have measured the expression in paired non-malignant and tumour tissues of CRC patients of nine lncRNAs previously shown to be involved in cancer progression-ANRIL, CCAT1, GAS5, linc-ROR, MALAT1, MIR155HG, PCAT1, SPRY4-IT1 and TUG1. A comparison of expression in tumour and non-malignant mucosa tissues showed significant upregulation of CCAT1 and linc-ROR in tumor tissue and downregulation of ANRIL, MIR155HG and MALAT1. Linc-ROR was significantly associated with the presence of synchronous metastases. For individual tissue types, lower MIR155HG expression in tumor tissue was correlated with both shorter overall survival and shorter disease-free survival. In non malignant tissue expression ratios of CCAT1/ANRIL and CCAT1/MIR155HG were significantly associated with overall survival. Our results revealed that changes in expression of lncRNAs between tumor and non-malignant issues could be used as prognostic biomarkers in CRC patients. Moreover, the ratios of CCAT1 to ANRIL and MIR155HG in non-malignant issue could be used for prognosis assessment. It seems that cancer progression is associated with detrimental system-wide changes in patient tissue, which might govern patient survival even after elimination of tumour.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30219 - Gastroenterology and hepatology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ISSN

1661-6596

e-ISSN

—

Svazek periodika

19

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

15

Strana od-do

—

Kód UT WoS článku

000449988100208

EID výsledku v databázi Scopus

2-s2.0-85053081079