MALAT1 in colorectal cancer: Its implication as a diagnostic, prognostic, and predictive biomarker

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F22%3A00567756" target="_blank" >RIV/68378041:_____/22:00567756 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/22:10446968 RIV/00216208:11140/22:10446968

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/abs/pii/S0378111922006102?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0378111922006102?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.gene.2022.146791" target="_blank" >10.1016/j.gene.2022.146791</a>

Jazyk výsledku

angličtina

Název v původním jazyce

MALAT1 in colorectal cancer: Its implication as a diagnostic, prognostic, and predictive biomarker

Popis výsledku v původním jazyce

Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1), originally described as a prognostic biomarker remarkably linked with metastasis potential in lung cancer, has been identified as contributing to many diseases, including colorectal cancer (CRC). This long non-coding RNA (lncRNA) has come to the forefront of lncRNA research for its implications in cancer-related processes, such as cell proliferation and migration. In general, lncRNAs are recognized as enhancers, scaffolds, or decoys for a variety of oncogenes and tumor sup-pressors, although our understanding of lncRNA functions and mechanisms of action is still limited. Nowadays, cancer research is attracted to lncRNAs' ability to improve the early diagnosis of cancer, determine patients' prognosis, or predict therapy outcomes. In this review, we aimed to evaluate recent publications trying to un-cover the cellular mechanisms of MALAT1-mediated regulation, and its potential exploitation in the management of CRC. The conclusions of this review provide robust support for the essential role of MALAT1 in CRC devel-opment and future personalized therapy.

Název v anglickém jazyce

MALAT1 in colorectal cancer: Its implication as a diagnostic, prognostic, and predictive biomarker

Popis výsledku anglicky

Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1), originally described as a prognostic biomarker remarkably linked with metastasis potential in lung cancer, has been identified as contributing to many diseases, including colorectal cancer (CRC). This long non-coding RNA (lncRNA) has come to the forefront of lncRNA research for its implications in cancer-related processes, such as cell proliferation and migration. In general, lncRNAs are recognized as enhancers, scaffolds, or decoys for a variety of oncogenes and tumor sup-pressors, although our understanding of lncRNA functions and mechanisms of action is still limited. Nowadays, cancer research is attracted to lncRNAs' ability to improve the early diagnosis of cancer, determine patients' prognosis, or predict therapy outcomes. In this review, we aimed to evaluate recent publications trying to un-cover the cellular mechanisms of MALAT1-mediated regulation, and its potential exploitation in the management of CRC. The conclusions of this review provide robust support for the essential role of MALAT1 in CRC devel-opment and future personalized therapy.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10601 - Cell biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Gene

ISSN

0378-1119

e-ISSN

1879-0038

Svazek periodika

843

Číslo periodika v rámci svazku

aug

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

146791

Kód UT WoS článku

000848450000001

EID výsledku v databázi Scopus

2-s2.0-85135889646