THE EFFECT OF POLY-E-CAPROLACTONE NANOFIBERS WITH PLATELETS ON CELL PROLIFERATION AND VIABILITY

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F19%3A00522982" target="_blank" >RIV/68378041:_____/19:00522982 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

THE EFFECT OF POLY-E-CAPROLACTONE NANOFIBERS WITH PLATELETS ON CELL PROLIFERATION AND VIABILITY

Popis výsledku v původním jazyce

Platelets are effective source of growth factors and other bioactive molecules. They can be combined with an appropriate scaffold where the mechanical properties of the scaffold and bioactive properties of platelets modulate cell behavior in the site of the injury. In this study, we compared different concentrations of platelets adhered on PCL nanofibers and evaluated their effect on mouse 3T3 fibroblasts. Platelets in maximum concentration significantly stimulated the viability when it is compared with control. Proliferation of fibroblasts was significantly higher than in the control group cultured on the plain scaffolds. Cells were well- spread on the scaffolds with adhered platelets, whereas on the plain scaffolds, the cells created clusters. The effect of platelets was dose-dependent. It is obvious, that the combination of bioactive substances and PLC nanofibres significantly stimulates cells growth and metabolic activity of the tested cell type.

Název v anglickém jazyce

THE EFFECT OF POLY-E-CAPROLACTONE NANOFIBERS WITH PLATELETS ON CELL PROLIFERATION AND VIABILITY

Popis výsledku anglicky

Platelets are effective source of growth factors and other bioactive molecules. They can be combined with an appropriate scaffold where the mechanical properties of the scaffold and bioactive properties of platelets modulate cell behavior in the site of the injury. In this study, we compared different concentrations of platelets adhered on PCL nanofibers and evaluated their effect on mouse 3T3 fibroblasts. Platelets in maximum concentration significantly stimulated the viability when it is compared with control. Proliferation of fibroblasts was significantly higher than in the control group cultured on the plain scaffolds. Cells were well- spread on the scaffolds with adhered platelets, whereas on the plain scaffolds, the cells created clusters. The effect of platelets was dose-dependent. It is obvious, that the combination of bioactive substances and PLC nanofibres significantly stimulates cells growth and metabolic activity of the tested cell type.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

30404 - Biomaterials (as related to medical implants, devices, sensors)

Projekt

<a href="/cs/project/LO1508" target="_blank" >LO1508: Genomika a proteomika při studiu mechanismů biologických účinků vyráběných nanočástic</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

NANOCON 2018 - Conference Proceedings, 10th Anniversary International Conference on Nanomaterials - Research and Application

ISBN

978-808729489-5

ISSN

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e-ISSN

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Počet stran výsledku

6

Strana od-do

477-482

Název nakladatele

Tanger Ltd.

Místo vydání

Ostrava

Místo konání akce

Brno

Datum konání akce

17. 10. 2018

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

000513131900083