Analyzing the mechanisms of iron oxide nanoparticles interactions with cells: A road from failure to success in clinical applications

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F20%3A00540031" target="_blank" >RIV/68378041:_____/20:00540031 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378271:_____/20:00537561 RIV/00023001:_____/20:00080456

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/abs/pii/S0168365920304776?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0168365920304776?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jconrel.2020.08.036" target="_blank" >10.1016/j.jconrel.2020.08.036</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Analyzing the mechanisms of iron oxide nanoparticles interactions with cells: A road from failure to success in clinical applications

Popis výsledku v původním jazyce

Iron oxide nanoparticles (IONPs) were the first generation of nanomaterials that reached real clinic use. Particularly, several IONPs-based magnetic resonance imaging contrast agents gained approval by US Food and Drug Administration (FDA). However, latter body of evidence revealed the overlooked side effects of IONPs, resulting in their withdrawal. Emerging evidence suggests that this happened due to poor understanding of the mechanisms by which IONPs act at the cellular and sub-cellular levels. Recent studies indicate that better understanding of fundamental signal modulations induced by nanomaterials is essential to overcome the clinical problems with nanoparticles. Therefore, in this article we critically review potential mechanisms of IONPs-cell interactions and challenges related with their identification. We describe mechanisms of IONPs-induced toxicity. Ultimately, we demonstrate that knowledge of cellular mechanisms of IONPs action helped to overcome certain translation problems in nanomedicine - we explore potential causes and challenges associated with poor clinical performance of IONPs and propose outlook of how to overcome problems in the field. Our critical analysis implies that a clear understanding of molecular mechanisms of IONPs-cell interactions will provide a basement to increase the likelihood for clinical success of IONPs.

Název v anglickém jazyce

Analyzing the mechanisms of iron oxide nanoparticles interactions with cells: A road from failure to success in clinical applications

Popis výsledku anglicky

Iron oxide nanoparticles (IONPs) were the first generation of nanomaterials that reached real clinic use. Particularly, several IONPs-based magnetic resonance imaging contrast agents gained approval by US Food and Drug Administration (FDA). However, latter body of evidence revealed the overlooked side effects of IONPs, resulting in their withdrawal. Emerging evidence suggests that this happened due to poor understanding of the mechanisms by which IONPs act at the cellular and sub-cellular levels. Recent studies indicate that better understanding of fundamental signal modulations induced by nanomaterials is essential to overcome the clinical problems with nanoparticles. Therefore, in this article we critically review potential mechanisms of IONPs-cell interactions and challenges related with their identification. We describe mechanisms of IONPs-induced toxicity. Ultimately, we demonstrate that knowledge of cellular mechanisms of IONPs action helped to overcome certain translation problems in nanomedicine - we explore potential causes and challenges associated with poor clinical performance of IONPs and propose outlook of how to overcome problems in the field. Our critical analysis implies that a clear understanding of molecular mechanisms of IONPs-cell interactions will provide a basement to increase the likelihood for clinical success of IONPs.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10610 - Biophysics

Projekt

<a href="/cs/project/LTC19040" target="_blank" >LTC19040: Rozvinuté fyzikální metody v studiích hepatotoxicity</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Controlled Release

ISSN

0168-3659

e-ISSN

—

Svazek periodika

328

Číslo periodika v rámci svazku

dec.

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

19

Strana od-do

59-77

Kód UT WoS článku

000600791600005

EID výsledku v databázi Scopus

2-s2.0-85089899628